Overview

  • Product nameAnti-CSN3 antibody
    See all CSN3 primary antibodies
  • Description
    Rabbit polyclonal to CSN3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 1-50 (MKSFLLVVNA LALTLPFLAV EVQNQKQPAC HENDERPFYQ KTAPYVPMYY) of Human CSN3 (NP_005203).

  • Positive control
    • Jurkat cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab111406 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 20 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceCSN3 is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • Cellular localizationSecreted
  • Database links
  • Alternative names
    • Casein Kappa antibody
    • COP9 Signalosome Complex Subunit 3 antibody
    • COPS3 antibody
    • CSN10 antibody
    • CSNK antibody
    • JAB1 Containing Signalosome Subunit 3 antibody
    • kappa-casein antibody
    • KCA antibody
    • SGN3 antibody
    • Signalosome Subunit 3 antibody
    see all

Anti-CSN3 antibody images

  • Anti-CSN3 antibody (ab111406) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 20 kDa

References for Anti-CSN3 antibody (ab111406)

ab111406 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"