Overview

  • Product nameAnti-CSN7b antibody
    See all CSN7b primary antibodies
  • Description
    Rabbit polyclonal to CSN7b
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Xenopus laevis, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis
  • Immunogen

    Immunogen was a synthetic peptide, which represented a portion of human constitutive photomorphogenic homolog 7b encoded within exon 10.

Properties

Applications

Our Abpromise guarantee covers the use of ab11895 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 33 kDa.

Target

  • FunctionComponent of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • Sequence similaritiesBelongs to the CSN7/EIF3M family. CSN7 subfamily.
    Contains 1 PCI domain.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • COP9 Complex Homolog Subunit 7b antibody
    • COP9 Constitutive Photomorphogenic Homolog Subunit 7b antibody
    • COP9 Signalasome Subunit 7b antibody
    • COP9 signalosome complex subunit 7b antibody
    • COPS7B antibody
    • CSN7B_HUMAN antibody
    • JAB1 Containing Signalosome Subunit 7b antibody
    • JAB1-containing signalosome subunit 7b antibody
    • SGN7b antibody
    • Signalosome subunit 7b antibody
    see all

Anti-CSN7b antibody images

  • RIPA lysate (50µg for E; 25µg for T) from HEK293T cells that were mock transfected (E) or transfected with a CSN7b construct (T). Antibody: ab11895 used at the indicated concentration. Detection: Chemiluminescence with an exposure time of 30 seconds.

References for Anti-CSN7b antibody (ab11895)

This product has been referenced in:
  • Oh W  et al. Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2. J Biol Chem 281:17457-65 (2006). Read more (PubMed: 16624822) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"