Overview

  • Product nameAnti-CSN7b antibody
    See all CSN7b primary antibodies
  • Description
    Rabbit polyclonal to CSN7b
  • Specificityab25800 recognises CSN7b.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Xenopus laevis, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis
  • Immunogen

    Synthetic peptide: SSSAQEMEQQ LAERECPPHA EQRQPTKKMS , corresponding to C terminal amino acids 225-264 of Human CSN7b.

  • Positive control
    • Whole cell lysate from HEK 293T cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab25800 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: 1/5000 - 1/25000. Predicted molecular weight: 32 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
    • Sequence similaritiesBelongs to the CSN7/EIF3M family. CSN7 subfamily.
      Contains 1 PCI domain.
    • Cellular localizationCytoplasm. Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • COP9 Complex Homolog Subunit 7b antibody
      • COP9 Constitutive Photomorphogenic Homolog Subunit 7b antibody
      • COP9 Signalasome Subunit 7b antibody
      • COP9 signalosome complex subunit 7b antibody
      • COPS7B antibody
      • CSN7B_HUMAN antibody
      • JAB1 Containing Signalosome Subunit 7b antibody
      • JAB1-containing signalosome subunit 7b antibody
      • SGN7b antibody
      • Signalosome subunit 7b antibody
      see all

    Anti-CSN7b antibody images

    • All lanes : Anti-CSN7b antibody (ab25800) (Whole cell lysate (50 µg – E; 10 µg - T) from HEK293T cells with (T) or without (E) a CSN7b expression construct. )

      Lane 1 : 0.2 µg antibody concentration.
      Lane 2 : 0.1 µg antibody concentration.
      Lane 3 : 0.04 µg antibody concentration.


      Predicted band size : 32 kDa

    References for Anti-CSN7b antibody (ab25800)

    ab25800 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab25800.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"