Overview

  • Product name
  • Description
    Rabbit polyclonal to CTDSP2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 26 - 256 of Human CTDSP2.

  • Positive control
    • 293T, A431, H1299 or Raji cell lysate.

Applications

Our Abpromise guarantee covers the use of ab97463 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 31 kDa.

Target

  • Function
    Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
  • Tissue specificity
    Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver.
  • Sequence similarities
    Contains 1 FCP1 homology domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 2 antibody
    • Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 antibody
    • conserved gene amplified in osteosarcoma 4 antibody
    • conserved gene amplified in osteosarcoma antibody
    • CTDS2_HUMAN antibody
    • Ctdsp2 antibody
    • NIF2 antibody
    • NLI interacting factor 2 antibody
    • NLI-interacting factor 2 antibody
    • Nuclear LIM interactor interacting factor 2 antibody
    • Nuclear LIM interactor-interacting factor 2 antibody
    • OS4 antibody
    • Protein OS 4 antibody
    • Protein OS-4 antibody
    • PSR2 antibody
    • SCP2 antibody
    • Small C-terminal domain phosphatase 2 antibody
    • Small CTD phosphatase 2 antibody
    see all

Images

  • Anti-CTDSP2 antibody (ab97463) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size : 31 kDa

References

This product has been referenced in:
  • Kloet DE  et al. FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1). Biochem J 469:289-98 (2015). Read more (PubMed: 25990325) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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