Overview

  • Product name
  • Description
    Goat polyclonal to CTDSPL
  • Specificity
    ab82617 is expected to recognise both isoforms (NP_001008393.1; NP_005799.2).
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity

    Predicted to work with: Chicken, Dog, Human
  • Immunogen

    Peptide with sequence

    QCNVSLKKQRSRS

    , corresponding to internal sequence amino acids 29-41 of Human CTDSPL (NP_001008393.1; NP_005799.2)

Properties

Applications

Our Abpromise guarantee covers the use of ab82617 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    Peptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1/32,000.
    WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 31 kDa.

    Preliminary experiments gave an approx 20kDa band in human placenta lysates after 1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 31.1kDa according to NP_NP_001008393.1 and of 29.9kDa according to NP_005799.2. The 20kDa band was successfully blocked by incubation with the immunizing peptide


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
    • Tissue specificity
      Expression is restricted to non-neuronal tissues.
    • Sequence similarities
      Contains 1 FCP1 homology domain.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • C3orf8 antibody
      • Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3 antibody
      • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like antibody
      • CTD small phosphatase-like protein antibody
      • CTDSL_HUMAN antibody
      • CTDSP-like antibody
      • Ctdspl antibody
      • hYA22 antibody
      • N-like protein antibody
      • NIF-like protein antibody
      • NLI-interacting factor 1 antibody
      • Nuclear LIM interactor-interacting factor 1 antibody
      • Protein YA22 antibody
      • RB protein serine phosphatase from chromosome 3 antibody
      • RBSP3 antibody
      • SCP3 antibody
      • Small C-terminal domain phosphatase 3 antibody
      • Small CTD phosphatase 3 antibody
      see all

    References

    ab82617 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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