Publishing research using ab6992? Please let us know so that we can cite the reference in this datasheet.

ab6992 has been referenced in 67 publications.

  • Zheng X  et al. Renal Sympathetic Denervation in Rats Ameliorates Cardiac Dysfunction and Fibrosis Post-Myocardial Infarction Involving MicroRNAs. Med Sci Monit 22:2751-60 (2016). IHC-P ; Rat . PubMed: 27490896
  • Li C  et al. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix. Nat Commun 7:11455 (2016). WB . PubMed: 27126736
  • Zhang ZH  et al. An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure. Sci Rep 6:22151 (2016). WB ; Rat . PubMed: 26903149
  • Cao YL  et al. TGF-ß1, in association with the increased expression of connective tissue growth factor, induce the hypertrophy of the ligamentum flavum through the p38 MAPK pathway. Int J Mol Med 38:391-8 (2016). WB ; Human . PubMed: 27279555
  • Yang Z  et al. Connective tissue growth factor stimulates the proliferation, migration and differentiation of lung fibroblasts during paraquat-induced pulmonary fibrosis. Mol Med Rep 12:1091-7 (2015). IHC-P . PubMed: 25815693
  • Xu H  et al. CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad6-CCN2 pathway: Potential role in epidural ?brosis. Int J Mol Med 36:123-9 (2015). Rat . PubMed: 25901787
  • Kim SS  et al. Nifedipine and phenytoin induce matrix synthesis, but not proliferation, in intact human gingival connective tissue ex vivo. J Cell Commun Signal 9:361-75 (2015). IHC-P ; Human . PubMed: 26296421
  • Singh KK  et al. The essential autophagy gene ATG7 modulates organ fibrosis via regulation of endothelial-to-mesenchymal transition. J Biol Chem 290:2547-59 (2015). WB ; Human . PubMed: 25527499
  • Van Aelst LN  et al. Osteoglycin prevents cardiac dilatation and dysfunction after myocardial infarction through infarct collagen strengthening. Circ Res 116:425-36 (2015). WB ; Mouse . PubMed: 25520363
  • Garrido P  et al. Iron-hepcidin dysmetabolism, anemia and renal hypoxia, inflammation and fibrosis in the remnant kidney rat model. PLoS One 10:e0124048 (2015). IHC-P ; Rat . PubMed: 25867633
  • Van Geest RJ  et al. Connective tissue growth factor is involved in structural retinal vascular changes in long-term experimental diabetes. J Histochem Cytochem 62:109-18 (2014). WB ; Mouse . PubMed: 24217924
  • Renard M  et al. Absence of cardiovascular manifestations in a haploinsufficient Tgfbr1 mouse model. PLoS One 9:e89749 (2014). IHC-P ; Mouse . PubMed: 24587008
  • Fehrholz M  et al. Caffeine and rolipram affect Smad signalling and TGF-ß1 stimulated CTGF and transgelin expression in lung epithelial cells. PLoS One 9:e97357 (2014). WB ; Human . PubMed: 24828686
  • Liang N  et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med 211:2249-63 (2014). WB ; Mouse . PubMed: 25288394
  • Wang X  et al. Topical Application of Recombinant Type VII Collagen Incorporates Into the Dermal-Epidermal Junction and Promotes Wound Closure. Mol Ther 21:1335-44 (2013). IHC (PFA fixed) ; Mouse . PubMed: 23670575
  • Tran CM  et al. Hypoxia-inducible factor (HIF)-1a and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1a level and transcriptional activity. J Biol Chem 288:12654-66 (2013). IHC-P, ICC/IF ; Mouse, Rat . PubMed: 23530034
  • Teles A  et al. Control of uterine microenvironment by foxp3(+) cells facilitates embryo implantation. Front Immunol 4:158 (2013). PubMed: 23801995
  • Tamaki S  et al. Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction. PLoS One 8:e68893 (2013). WB ; Mouse . PubMed: 23894370
  • Wang C  et al. Metabolic syndrome-induced tubulointerstitial injury: Role of oxidative stress and preventive effects of acetaminophen. Free Radic Biol Med 65C:1417-1426 (2013). Rat . PubMed: 24140865
  • Basford JE  et al. Smooth Muscle LDL Receptor-Related Protein-1 Deletion Induces Aortic Insufficiency and Promotes Vascular Cardiomyopathy in Mice. PLoS One 8:e82026 (2013). IHC-P ; Mouse . PubMed: 24312398
  • Samarakoon R  et al. Induction of renal fibrotic genes by TGF-ß1 requires EGFR activation, p53 and reactive oxygen species. Cell Signal 25:2198-209 (2013). PubMed: 23872073
  • Nakashima T  et al. Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts. J Immunol 188:3573-83 (2012). PubMed: 22403442
  • Nakagawa N  et al. The intrinsic prostaglandin E(2)-EP(4) system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice. Kidney Int : (2012). PubMed: 22513820
  • Yu X  et al. The balance of beneficial and deleterious effects of hypoxia-inducible factor activation by prolyl hydroxylase inhibitor in rat remnant kidney depends on the timing of administration. Nephrol Dial Transplant : (2012). WB ; Rat . PubMed: 22399494
  • Haafiz A  et al. Relationship between hepatic CTGF expression and routine blood tests at the time of liver transplantation for biliary atresia: hope or hype for a biomarker of hepatic fibrosis. Clin Exp Gastroenterol 4:49-54 (2011). IHC-P ; Human . PubMed: 21694872
  • Yang L  et al. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 16:535-43, 1p following 143 (2010). WB ; Mouse . PubMed: 20436483
  • Shi-wen X  et al. Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts. Rheumatology (Oxford) 49:259-63 (2010). WB ; Human . PubMed: 20007285
  • Ibba-Manneschi L  et al. Severe fibrotic changes and altered expression of angiogenic factors in maternal scleroderma: placental findings. Ann Rheum Dis 69:458-61 (2010). IHC-P ; Human . PubMed: 19336420
  • Qiu Z  et al. c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci U S A 107:1136-41 (2010). WB ; Mouse . PubMed: 20080568
  • Liu S  et al. Connective tissue growth factor is induced in bleomycin-induced skin scleroderma. J Cell Commun Signal : (2009). PubMed: 19916059
  • Gaultier A  et al. Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci 122:1155-62 (2009). IHC-Fr ; Human . PubMed: 19299462
  • Mesas-Burgos C  et al. Gene expression analysis after prenatal tracheal ligation in fetal rat as a model of stimulated lung growth. J Pediatr Surg 44:720-8 (2009). PubMed: 19361631
  • Duisters RF  et al. miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ Res 104:170-8, 6p following 178 (2009). WB ; Human . PubMed: 19096030
  • Mitani A  et al. Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice. Am J Respir Crit Care Med 180:326-38 (2009). PubMed: 19498055
  • Pala D  et al. Focal Adhesion Kinase/Src Suppresses Early Chondrogenesis: CENTRAL ROLE OF CCN2. J Biol Chem 283:9239-9247 (2008). WB . PubMed: 18276598
  • Kato T  et al. AGEs-RAGE system mediates atrial structural remodeling in the diabetic rat. J Cardiovasc Electrophysiol 19:415-20 (2008). WB ; Rat . PubMed: 18298515
  • Hora C  et al. Connective tissue growth factor, steatosis and fibrosis in patients with chronic hepatitis C. Liver Int 28:370-6 (2008). PubMed: 17976159
  • Fernández P  et al. Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine. Am J Pathol 172:1675-82 (2008). WB, IHC-P ; Mouse . PubMed: 18467695
  • Smith MM  et al. Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy. Rheumatology (Oxford) 47:1172-8 (2008). IHC-P ; Sheep . PubMed: 18565987
  • Kuiper EJ  et al. Effect of VEGF-A on expression of profibrotic growth factor and extracellular matrix genes in the retina. Invest Ophthalmol Vis Sci 48:4267-76 (2007). PubMed: 17724216
  • Manetti M  et al. Severe fibrosis and increased expression of fibrogenic cytokines in the gastric wall of systemic sclerosis patients. Arthritis Rheum 56:3442-7 (2007). IHC-P ; Human . PubMed: 17907149
  • Mezzano S  et al. Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis. Nephrol Dial Transplant 22:1882-90 (2007). PubMed: 17403698
  • Xie S  et al. Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta. Am J Physiol Lung Cell Mol Physiol 293:L245-53 (2007). WB ; Human . PubMed: 17468136
  • Yevdokimova N & Podpryatov S The up-regulation of angiotensin II receptor type 1 and connective tissue growth factor are involved in high-glucose-induced fibronectin production by cultured human dermal fibroblasts. J Dermatol Sci 47:127-39 (2007). PubMed: 17399955
  • Guha M  et al. Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes. FASEB J 21:3355-68 (2007). WB, IHC-P ; Mouse . PubMed: 17554073
  • Koepke ML  et al. Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome. Nephrol Dial Transplant 22:1062-9 (2007). PubMed: 17287218
  • Burgess JK  et al. Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix. Am J Physiol Lung Cell Mol Physiol 290:L153-61 (2006). IP ; Human . PubMed: 16100286
  • Portik-Dobos V  et al. Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes. Am J Physiol Regul Integr Comp Physiol 290:R435-41 (2006). PubMed: 16239374
  • Gómez-Garre D  et al. Losartan improves resistance artery lesions and prevents CTGF and TGF-beta production in mild hypertensive patients. Kidney Int 69:1237-44 (2006). PubMed: 16482098
  • Dean RG  et al. Connective tissue growth factor and cardiac fibrosis after myocardial infarction. J Histochem Cytochem 53:1245-56 (2005). PubMed: 15956033
  • Zhao Z  et al. Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology. FASEB J 19:2081-2 (2005). PubMed: 16186174
  • Xie S  et al. Regulation of TGF-beta 1-induced connective tissue growth factor expression in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 288:L68-76 (2005). WB ; Human . PubMed: 15377500
  • Shin JY  et al. HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-beta1. Exp Mol Med 37:138-45 (2005). PubMed: 15886528
  • Pi L  et al. Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF/PHx in rats. Gastroenterology 128:2077-88 (2005). PubMed: 15940639
  • Ozaki S  et al. Diffuse expression of heparan sulfate proteoglycan and connective tissue growth factor in fibrous septa with many mast cells relate to unresolving hepatic fibrosis of congenital hepatic fibrosis. Liver Int 25:817-28 (2005). PubMed: 15998433
  • Gross O  et al. Nephroprotection by antifibrotic and anti-inflammatory effects of the vasopeptidase inhibitor AVE7688. Kidney Int 68:456-63 (2005). PubMed: 16014022
  • Danda RS  et al. Kidney involvement in a nongenetic rat model of type 2 diabetes. Kidney Int 68:2562-71 (2005). PubMed: 16316331
  • Bäcklund T  et al. Sustained cardiomyocyte apoptosis and left ventricular remodelling after myocardial infarction in experimental diabetes. Diabetologia 47:325-30 (2004). PubMed: 14722653
  • Gross O  et al. Antifibrotic, nephroprotective potential of ACE inhibitor vs AT1 antagonist in a murine model of renal fibrosis. Nephrol Dial Transplant 19:1716-23 (2004). PubMed: 15128880
  • Pörsti I  et al. High calcium diet down-regulates kidney angiotensin-converting enzyme in experimental renal failure. Kidney Int 66:2155-66 (2004). PubMed: 15569305
  • Hoek K  et al. Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res 64:5270-82 (2004). PubMed: 15289333
  • Candido R  et al. A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes. Circ Res 92:785-92 (2003). PubMed: 12623881
  • Razzaque MS  et al. Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci 44:1998-2003 (2003). PubMed: 12714635
  • Ueberham U  et al. Connective tissue growth factor in Alzheimer's disease. Neuroscience 116:1-6 (2003). PubMed: 12535930
  • Finckenberg P  et al. Angiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathways. Am J Pathol 163:355-66 (2003). PubMed: 12819040
  • Inkinen K  et al. Connective tissue growth factor and its correlation to other growth factors in experimental granulation tissue. Connect Tissue Res 44:19-29 (2003). PubMed: 12945801
  • Fu M  et al. Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J Biol Chem 276:45888-94 (2001). PubMed: 11590167

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"