Overview

  • Product name
  • Description
    Goat polyclonal to Cullin 2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Cow, Dog, Human
  • Immunogen

    Synthetic peptide:

    QYIERSQASADE

    by a Cysteine residue linker, corresponding to C terminal amino acids 729-740 of Human Cullin 2 (NP_003582.2)

  • Positive control
    • NIH3T3 lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab101712 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 87 kDa.

Target

  • Function
    Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the cullin family.
  • Post-translational
    modifications
    CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cul2 antibody
    • CUL 2 antibody
    • CUL-2 antibody
    • CUL2 antibody
    • CUL2_HUMAN antibody
    • cullin 2 antibody
    • cullin homolog 2 antibody
    • Cullin-2 antibody
    • MGC131970 antibody
    see all

Images

  • Anti-Cullin 2 antibody (ab101712) at 1 µg/ml + NIH3T3 cell lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 87 kDa

References

ab101712 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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