Overview

  • Product name
  • Description
    Rabbit polyclonal to Cullin 2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Human Cullin 2 aa 40-310.
    Database link: Q13617

  • Positive control
    • PC3, K562, HL60, 293T and OVCAR3 cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab187504 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 87 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function
    Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the cullin family.
  • Post-translational
    modifications
    CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cul2 antibody
    • CUL 2 antibody
    • CUL-2 antibody
    • CUL2 antibody
    • CUL2_HUMAN antibody
    • cullin 2 antibody
    • cullin homolog 2 antibody
    • Cullin-2 antibody
    • MGC131970 antibody
    see all

Images

  • All lanes : Anti-Cullin 2 antibody (ab187504) at 1/500 dilution

    Lane 1 : PC3 cell extract
    Lane 2 : K562 cell extract
    Lane 3 : HL60 cell extract
    Lane 4 : 293T cell extract
    Lane 5 : OVCAR3 cell extract

    Predicted band size: 87 kDa

References

ab187504 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab187504.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up