Overview

  • Product name
  • Description
    Rabbit polyclonal to CXCL16
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 52-193 of Human CXCL16 (AAH17588).

  • Positive control
    • A549, HepG2 whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab101404 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 28 kDa.
IHC-P 1/100 - 1/500. Antigen retrieval is recommended using heat mediated 10mM Citrate buffer or Tris-EDTA buffer (pH: 8.0)

Target

  • Function
    Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
  • Tissue specificity
    Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
  • Sequence similarities
    Belongs to the intercrine alpha (chemokine CxC) family.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localization
    Cell membrane. Secreted. Also exists as a soluble form.
  • Information by UniProt
  • Database links
  • Alternative names
    • C-X-C motif chemokine 16 antibody
    • Chemokine (C X C motif) ligand 16 antibody
    • Chemokine, CXC motif, ligand 16 antibody
    • CXC chemokine ligand 16 antibody
    • Cxcl16 antibody
    • CXCLG16 antibody
    • CXL16_HUMAN antibody
    • Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein antibody
    • SCYB16 antibody
    • Small inducible cytokine B16 precursor antibody
    • Small-inducible cytokine B16 antibody
    • SR-PSOX antibody
    • SRPSOX antibody
    • Transmembrane chemokine CXCL16 antibody
    • UNQ2759/PRO6714 antibody
    see all

Images

  • Anti-CXCL16 antibody (ab101404) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 28 kDa
  • Immunohistochemical analysis of paraffin-embedded H661 xenograft, using ab101404 at 1/100 dilution.

References

This product has been referenced in:
  • Cho SW  et al. CXCL16 signaling mediated macrophage effects on tumor invasion of papillary thyroid carcinoma. Endocr Relat Cancer 23:113-24 (2016). Read more (PubMed: 26559672) »
  • Zhang R  et al. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature 535:164-8 (2016). Read more (PubMed: 27383988) »

See all 6 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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