1/100 - 1/500. Antigen retrieval is recommended using heat mediated 10mM Citrate buffer or Tris-EDTA buffer (pH: 8.0)
FunctionActs as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Tissue specificityExpressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family.
Cellular localizationCell membrane. Secreted. Also exists as a soluble form.
Immunohistochemical analysis of paraffin-embedded H661 xenograft, using ab101404 at 1/100 dilution.
References for Anti-CXCL16 antibody (ab101404)
This product has been referenced in:
Ali-Rahmani F et al. C282Y-HFE gene variant affects cholesterol metabolism in human neuroblastoma cells. PLoS One9:e88724 (2014).
Read more (PubMed: 24533143) »
Voloshyna I et al. Plasma from rheumatoid arthritis patients promotes pro-atherogenic cholesterol transport gene expression in THP-1 human macrophages. Exp Biol Med (Maywood)238:1192-7 (2013).
Read more (PubMed: 24000379) »