Anti-CXCR2 antibody [MM0222-7J40] (ab89254)

Overview

  • Product nameAnti-CXCR2 antibody [MM0222-7J40]
    See all CXCR2 primary antibodies
  • Description
    Mouse monoclonal [MM0222-7J40] to CXCR2
  • Tested applicationsSuitable for: IHC-Fr, Neutralising, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human recombinant CXCR2

Properties

Applications

Our Abpromise guarantee covers the use of ab89254 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/20 - 1/100.
Neutralising Use at an assay dependent concentration.
Flow Cyt 1/50 - 1/200. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • FunctionReceptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    Phosphorylated upon ligand binding; which is required for desensitization.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C-X-C chemokine receptor type 2 antibody
    • CD 182 antibody
    • CD182 antibody
    • CD182 antigen antibody
    • CDw128b antibody
    • Chemokine (CXC) receptor 2 antibody
    • CMKAR2 antibody
    • CXC-R2 antibody
    • CXCR 2 antibody
    • CXCR-2 antibody
    • CXCR2 antibody
    • CXCR2_HUMAN antibody
    • GRO/MGSA receptor antibody
    • High affinity interleukin-8 receptor B antibody
    • IL 8 receptor type 2 antibody
    • IL 8R B antibody
    • IL-8 receptor type 2 antibody
    • IL-8R B antibody
    • IL8 RB antibody
    • IL8 receptor type 2 antibody
    • IL8R B antibody
    • IL8R2 antibody
    • IL8RA antibody
    • Interleukin 8 Receptor B antibody
    • Interleukin 8 receptor, beta antibody
    • Interleukin 8 receptor, type 2 antibody
    see all

References for Anti-CXCR2 antibody [MM0222-7J40] (ab89254)

ab89254 has not yet been referenced specifically in any publications.

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I am pleased to have received some furhter ifnormation from the originator for you. They have confirmed that no special IHC-Fr procedure woudl be required, you can use a standard procedure such as...

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With antibodies these two terms have similar meaning i.e. antibodies inhibit or neutralizes the cellular response either by binding to receptors, ligand or other cell signalling downstream proteins.

ab1...

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