Validated using a knockout cell line

Anti-CXCR4 antibody [UMB2] (ab124824)

Publishing research using ab124824? Please let us know so that we can cite the reference in this datasheet.

ab124824 has been referenced in 59 publications.

  • Habringer S  et al. Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics. Theranostics 8:369-383 (2018). PubMed: 29290814
  • Wang R  et al. Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM). Med Sci Monit 24:412-420 (2018). PubMed: 29353288
  • Pan Z  et al. miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis. J Neuroinflammation 15:29 (2018). PubMed: 29386025
  • Liu Q  et al. In vitro cell behaviors of bone mesenchymal stem cells derived from normal and postmenopausal osteoporotic rats. Int J Mol Med 41:669-678 (2018). WB, ICC/IF ; Rat . PubMed: 29207050
  • Zheng J  et al. Modulatory effects of trophoblast-secreted CXCL12 on the migration and invasion of human first-trimester decidual epithelial cells are mediated by CXCR4 rather than CXCR7. Reprod Biol Endocrinol 16:17 (2018). PubMed: 29499763
  • Jiang X  et al. Targeting Tumor Hypoxia Using Nanoparticle-engineered CXCR4-overexpressing Adipose-derived Stem Cells. Theranostics 8:1350-1360 (2018). PubMed: 29507625
  • Breun M  et al. CXCR4: A new player in vestibular schwannoma pathogenesis. Oncotarget 9:9940-9950 (2018). PubMed: 29515781
  • Katsura M  et al. Correlation between CXCR4/CXCR7/CXCL12 chemokine axis expression and prognosis in lymph-node-positive lung cancer patients. Cancer Sci 109:154-165 (2018). IHC-P ; Human . PubMed: 29032612
  • Kaemmerer D  et al. Somatostatin and CXCR4 chemokine receptor expression in hepatocellular and cholangiocellular carcinomas: tumor capillaries as promising targets. BMC Cancer 17:896 (2017). IHC-P ; Human . PubMed: 29282035
  • Jackson EK  et al. SDF-1a (Stromal Cell-Derived Factor 1a) Induces Cardiac Fibroblasts, Renal Microvascular Smooth Muscle Cells, and Glomerular Mesangial Cells to Proliferate, Cause Hypertrophy, and Produce Collagen. J Am Heart Assoc 6:N/A (2017). WB . PubMed: 29114002
  • Salgia R  et al. A randomized phase II study of LY2510924 and carboplatin/etoposide versus carboplatin/etoposide in extensive-disease small cell lung cancer. Lung Cancer 105:7-13 (2017). IHC-P ; Human . PubMed: 28236984
  • Kim YH  et al. Senescent tumor cells lead the collective invasion in thyroid cancer. Nat Commun 8:15208 (2017). WB . PubMed: 28489070
  • Yu J  et al. Isolation and identification of tumor-initiating cell properties in human gallbladder cancer cell lines using the marker cluster of differentiation 133. Oncol Lett 14:7111-7120 (2017). PubMed: 29344142
  • Xiao D  et al. Adipose-derived stem cells-seeded bladder acellular matrix graft-silk fibroin enhances bladder reconstruction in a rat model. Oncotarget 8:86471-86487 (2017). WB . PubMed: 29156809
  • Kaemmerer D  et al. Evaluation of somatostatin, CXCR4 chemokine and endothelin A receptor expression in a large set of paragangliomas. Oncotarget 8:89958-89969 (2017). PubMed: 29163802
  • Boyé K  et al. The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors. Nat Commun 8:1571 (2017). PubMed: 29146996
  • Seemann S  et al. Comprehensive comparison of three different animal models for systemic inflammation. J Biomed Sci 24:60 (2017). PubMed: 28836970
  • Veenstra VL  et al. Stromal SPOCK1 supports invasive pancreatic cancer growth. Mol Oncol N/A:N/A (2017). IHC-P ; Mouse . PubMed: 28486750
  • Cives M  et al. Osteotropism of neuroendocrine tumors: role of the CXCL12/ CXCR4 pathway in promoting EMT in vitro. Oncotarget 8:22534-22549 (2017). ICC/IF ; Human . PubMed: 28186979
  • Xu XD  et al. Anti-RhoC siRNAs inhibit the proliferation and invasiveness of breast cancer cells via modulating the KAI1, MMP9, and CXCR4 expression. Onco Targets Ther 10:1827-1834 (2017). WB ; Human . PubMed: 28367066
  • Wang Y  et al. Stromal cell-derived factor-1a and transforming growth factor-ß1 synergistically facilitate migration and chondrogenesis of synovium-derived stem cells through MAPK pathways. Am J Transl Res 9:2656-2667 (2017). PubMed: 28560013
  • Weiss ID  et al. Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using 64Cu-plerixafor PET. Oncotarget 8:73387-73406 (2017). IHC-P . PubMed: 29088715
  • Manetti M  et al. Angiogenic T cell expansion correlates with severity of peripheral vascular damage in systemic sclerosis. PLoS One 12:e0183102 (2017). PubMed: 28797111
  • Yang J  et al. Berberine ameliorates non-alcoholic steatohepatitis in ApoE-/- mice. Exp Ther Med 14:4134-4140 (2017). PubMed: 29075339
  • Mimura-Yamamoto Y  et al. Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development. Sci Rep 7:5647 (2017). IHC ; Mouse . PubMed: 28717168
  • Marques CS  et al. Serum SDF-1 levels are a reliable diagnostic marker of feline mammary carcinoma, discriminating HER2-overexpressing tumors from other subtypes. Oncotarget 8:105775-105789 (2017). IHC-P ; Human . PubMed: 29285291
  • Wang Y  et al. Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis. Biomaterials 101:108-20 (2016). WB . PubMed: 27267632
  • Zhang L  et al. CXCR4 activation promotes differentiation of human embryonic stem cells to neural stem cells. Neuroscience N/A:N/A (2016). WB ; Human . PubMed: 27615032
  • Herhaus P  et al. Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia. Haematologica 101:932-40 (2016). IHC ; Human . PubMed: 27175029
  • Shi H  et al. Long non-coding RNA expression profile in minor salivary gland of primary Sjögren's syndrome. Arthritis Res Ther 18:109 (2016). IHC ; Human . PubMed: 27188286
  • Lu W  et al. CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model. Int J Mol Sci 17:N/A (2016). WB, ICC/IF ; Rat . PubMed: 27690009
  • Stollberg S  et al. Differential somatostatin and CXCR4 chemokine receptor expression in MALT-type lymphoma of gastric and extragastric origin. J Cancer Res Clin Oncol 142:2239-47 (2016). PubMed: 27544389
  • Hyafil F  et al. Imaging the cytokine receptor CXCR4 in atherosclerotic plaques with the radiotracer 68Ga-pentixafor for positron emission tomography. J Nucl Med N/A:N/A (2016). PubMed: 27789718
  • Liu Z  et al. SDF-1/CXCR4 axis induces apoptosis of human degenerative nucleus pulposus cells via the NF-?B pathway. Mol Med Rep 14:783-9 (2016). IHC-P ; Human . PubMed: 27220474
  • Deveza L  et al. Polymer-DNA Nanoparticle-Induced CXCR4 Overexpression Improves Stem Cell Engraftment and Tissue Regeneration in a Mouse Hindlimb Ischemia Model. Theranostics 6:1176-89 (2016). WB ; Human . PubMed: 27279910
  • Marchica V  et al. Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin? Int J Hematol N/A:N/A (2016). PubMed: 27699576
  • Sun J  et al. Modulation of stromal cell-derived factor 1 alpha (SDF-1a) and its receptor CXCR4 in Porphyromonas gingivalis-induced periodontal inflammation. BMC Oral Health 17:26 (2016). IHC-P . PubMed: 27449062
  • Moreno MJ  et al. CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival. J Pathol 235:445-55 (2015). Human . PubMed: 25231113
  • Malik A  et al. Exogenous SDF-1a Protects Human Myocardium from Hypoxia-Reoxygenation Injury via CXCR4. Cardiovasc Drugs Ther N/A:N/A (2015). IHC-Fr, IF ; Human . PubMed: 26482377
  • Gong HY  et al. Radiation-induced pulmonary injury accelerated pulmonary metastasis in a mouse model of breast cancer. Oncol Lett 10:3613-3618 (2015). IHC-P ; Mouse . PubMed: 26788178
  • Stanisavljevic L  et al. CXCR4, CXCL12 and the relative CXCL12-CXCR4 expression as prognostic factors in colon cancer. Tumour Biol N/A:N/A (2015). IHC ; Human . PubMed: 26678887
  • Tanios F  et al. CXCR4: A Potential Marker for Inflammatory Activity in Abdominal Aortic Aneurysm Wall. Eur J Vasc Endovasc Surg 50:745-53 (2015). IHC ; Human . PubMed: 26346005
  • Masuda T  et al. ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling. Sci Rep 5:9170 (2015). WB, IHC ; Human . PubMed: 25773070
  • Philipp-Abbrederis K  et al. In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma. EMBO Mol Med 7:477-87 (2015). WB, IHC-P ; Human . PubMed: 25736399
  • Wester HJ  et al. Disclosing the CXCR4 expression in lymphoproliferative diseases by targeted molecular imaging. Theranostics 5:618-30 (2015). IHC ; Human . PubMed: 25825601
  • Wu WC  et al. Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients. Proc Natl Acad Sci U S A 111:4221-6 (2014). Human . PubMed: 24591638
  • Van Langendonckt A  et al. Gene expression in human ovarian tissue after xenografting. Mol Hum Reprod 20:514-25 (2014). PubMed: 24586055
  • Wheat R  et al. Inflammatory cell distribution in primary merkel cell carcinoma. Cancers (Basel) 6:1047-64 (2014). IHC-P ; Human . PubMed: 24961933
  • Satomura H  et al. Can expression of CXCL12 and CXCR4 be used to predict survival of gastric cancer patients? Anticancer Res 34:4051-7 (2014). PubMed: 25075029
  • Abe P  et al. CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons. Development 141:1857-63 (2014). IHC ; Human . PubMed: 24718993
  • Alamo P  et al. Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models. Dis Model Mech 7:387-96 (2014). IHC-P . PubMed: 24487410
  • Schultheiß C  et al. CXCR4 prevents dispersion of granule neuron precursors in the adult dentate gyrus. Hippocampus 23:1345-58 (2013). PubMed: 23929505
  • Lei PP  et al. Fibrocytes are associated with the fibrosis of coronary heart disease. Pathol Res Pract 209:36-43 (2013). ICC/IF ; Human . PubMed: 23177618
  • Yang S  et al. Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons. Development 140:4554-64 (2013). ICC/IF . PubMed: 24154522
  • Mueller W  et al. Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus. PLoS One 8:e64975 (2013). WB ; Human . PubMed: 23734232
  • Chen Z  et al. Tumor Microenvironment Varies under Different TCM ZHENG Models and Correlates with Treatment Response to Herbal Medicine. Evid Based Complement Alternat Med 2012:635702 (2012). PubMed: 22690248
  • Baumhoer D  et al. Strong expression of CXCL12 is associated with a favorable outcome in osteosarcoma. Mod Pathol 25:522-8 (2012). Human . PubMed: 22173290
  • Sánchez-Alcañiz JA  et al. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron 69:77-90 (2011). PubMed: 21220100
  • Fischer T  et al. Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2. PLoS One 3:e4069 (2008). ICC/IF ; Human . PubMed: 19116653


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