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Anti-Cyclin A antibody (ab7956)

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Overview

Product name

Anti-Cyclin A antibody
See all Cyclin A products (20) ...

Description

Rabbit polyclonal to Cyclin A

Specificity

Reacts with cyclin A2.

Tested applications

ICC/IF, IHC-Fr, IP, WB, IHC-Pmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Synthetic peptide: HSKYHSVSLLNPPETLSV, corresponding to C terminal amino acids 405-422 of Mouse Cyclin A.

HSKYHSVSLL NPPETLSV

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

K562, HeLa

Properties

Form

Liquid

Storage instructions

Store at +4°C. Do not freeze.

Storage buffer

PBS with 0.1% sodium azide

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Polyclonal

Isotype

IgG

Research areas

Cardiovascular >> Lipids / Lipoproteins >> Lipoproteins/Apolipoproteins >> Apolipoproteins
Cancer >> Cell cycle >> Cyclins >> Cyclin A family
Epigenetics and Nuclear Signaling >> Cell cycle >> Cyclins >> Cyclin A Family
Cell Biology >> Cell Cycle >> Cyclins >> Cyclin A Family
Cell Biology >> Cell Cycle >> Cyclins

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cyclin A antibody (ab7956)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cyclin A antibody (ab7956) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab7956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.

Sequence similarities

Belongs to the cyclin family. Cyclin AB subfamily.

Developmental stage

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Cellular localization

Nucleus. Cytoplasm. Cytoplasmic when associated with SCAPER.

Target information above from: UniProt accessionP20248 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CCN1 antibody
  • CCNA antibody
  • CCNA2 antibody
  • CCNA2_HUMAN antibody
  • Cyclin A2 antibody
  • Cyclin-A antibody
  • Cyclin-A2 antibody
see all

Database links

see all

Anti-Cyclin A antibody images:

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cyclin A antibody (ab7956)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cyclin A antibody (ab7956)

ab7956 at 1/150 staining developing mouse embryo tissue sections (5 microns) by IHC-P. The tissue was formaldehyde fixed and and heat mediated antigen retrieval step in citric acid buffer was performed. The tissue was blocked in BSA and incubated with the antibody for 2 hours. A biotinylated goat antibody was used as the secondary. The image shows T/S of developing oesophagus, trachea, skeletal muscle and blood vessel wall.

This image is courtesy of an Abreview submitted by Mr Carl hobbs

See Abreview

References for Anti-Cyclin A antibody (ab7956)

This product has been referenced in:

  • Pascreau Get al. Discovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding. Proc Natl Acad Sci U S A 107:2932-7 (2010). ICC/IF; Human.Read more (PubMed: 20133761) »
  • Ramathal Cet al. Lack of CCAAT enhancer binding protein beta (C/EBPbeta) in uterine epithelial cells impairs estrogen-induced DNA replication, induces DNA damage response pathways, and promotes apoptosis. Mol Cell Biol 30:1607-19 (2010). IHC-P; Mouse.Read more (PubMed: 20086097) »

See all 14 publications for this product

Publishing research using ab7956? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"