Overview

  • Product name
    Anti-Cyclin B1 antibody [V143.1]
    See all Cyclin B1 primary antibodies
  • Description
    Mouse monoclonal [V143.1] to Cyclin B1
  • Specificity
    Exceptionally good at detecting cyclin B1 in western blots, giving a very strong signal with no background.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Full length protein corresponding to Hamster Cyclin B1.
    Database link: P14635

  • Epitope
    Within a region spanning the carboxy region.

Properties

Applications

Our Abpromise guarantee covers the use of ab18219 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 58 kDa.

Target

  • Function
    Essential for the control of the cell cycle at the G2/M (mitosis) transition.
  • Sequence similarities
    Belongs to the cyclin family. Cyclin AB subfamily.
  • Developmental stage
    Accumulates steadily during G2 and is abruptly destroyed at mitosis.
  • Post-translational
    modifications
    Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
  • Cellular localization
    Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • CCNB 1 antibody
    • CCNB antibody
    • ccnb1 antibody
    • CCNB1_HUMAN antibody
    • Cyclin B1 antibody
    • G2 mitotic specific cyclin B1 antibody
    • G2/mitotic-specific cyclin-B1 antibody
    see all

References

This product has been referenced in:
  • Ding Z  et al. OLA1, a Translational Regulator of p21, Maintains Optimal Cell Proliferation Necessary for Developmental Progression. Mol Cell Biol 36:2568-82 (2016). Read more (PubMed: 27481995) »
  • Shen W  et al. Female infertility in PDE3A (-/-) mice: Polo-like kinase 1 (Plk1) may be a target of Protein Kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A (-/- ) mice. Cell Cycle 9:4720-34 (2010). WB ; Mouse . Read more (PubMed: 21099356) »

See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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