Overview

  • Product nameAnti-Cyclin C antibody
    See all Cyclin C primary antibodies
  • Description
    Rabbit polyclonal to Cyclin C
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus (Ornithorhynchus anatinus)
  • Immunogen

    Synthetic peptide derived from the C terminal region of Human Cyclin C (NP_005181.2)

  • Positive control
    • Pancreatic islet cell tumor or skin squamous cell carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab105046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. Likely to work with frozen sections

Target

  • FunctionComponent of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
  • Tissue specificityHighest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
  • Sequence similaritiesBelongs to the cyclin family. Cyclin C subfamily.
    Contains 1 cyclin N-terminal domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • ccnc antibody
    • CCNC_HUMAN antibody
    • CycC antibody
    • Cyclin C antibody
    • Cyclin-C antibody
    • hSRB11 antibody
    • OTTHUMP00000016897 antibody
    • SRB11 homolog antibody
    see all

Anti-Cyclin C antibody images

  • ab105046 at 1/100 dilution staining Cyclin C in formalin-fixed, paraffin-embedded Human skin squamous cell carcinomatissue.
    Detection: DAB staining.
  • ab105046 at 1/100 dilution staining Cyclin C in formalin-fixed, pParaffin-embedded Human pancreatic islet cell tumor tissue.
    Detection: DAB staining.

References for Anti-Cyclin C antibody (ab105046)

ab105046 has not yet been referenced specifically in any publications.

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