Overview

  • Product name
  • Description
    Rabbit polyclonal to Cyclin C
  • Tested applications
    Suitable for: WB, IP, ICC/IF, Functional Studiesmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Dog, Human
    Predicted to work with: Chicken, Cow, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to Human Cyclin C aa 270-283 (C terminal) (Cysteine residue).
    Sequence:

    C-QGPNGSQNSSYSQS

  • Positive control
    • HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab80910 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 5 - 10 µg/ml. Predicted molecular weight: 33 kDa.
IP Use at 10 µg/mg of lysate.
ICC/IF Use at an assay dependent concentration.
Functional Studies Use at an assay dependent concentration.

Kinase assay.

Target

  • Function
    Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
  • Tissue specificity
    Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
  • Sequence similarities
    Belongs to the cyclin family. Cyclin C subfamily.
    Contains 1 cyclin N-terminal domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • ccnc antibody
    • CCNC_HUMAN antibody
    • CycC antibody
    • Cyclin C antibody
    • Cyclin-C antibody
    • hSRB11 antibody
    • OTTHUMP00000016897 antibody
    • SRB11 homolog antibody
    see all

References

ab80910 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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