• Product nameAnti-Cyclin E2 antibody [EP454Y]
    See all Cyclin E2 primary antibodies
  • Description
    Rabbit monoclonal [EP454Y] to Cyclin E2
  • Tested applicationsSuitable for: WB, IHC-P, ICC/IF, IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human)

  • Positive control
    • Jurkat cell lysate, HeLa cells, human breast carcinoma (IHC-P).
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    A trial size is available to purchase for this antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Alternative versions available:

    Anti-Cyclin E2 antibody (Alexa Fluor® 488) [EP454Y] (ab200423)

    Anti-Cyclin E2 antibody (Alexa Fluor® 647) [EP454Y] (ab200424)

    Anti-Cyclin E2 antibody (HRP) [EP454Y] (ab200425)


Associated products


Our Abpromise guarantee covers the use of ab40890 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).
IHC-P 1/250 - 1/500.
ICC/IF 1/100 - 1/250.
IP 1/50.


  • RelevanceThe human Cyclin E2 gene encodes a 404 amino acid protein that is most closely related to Cyclin E. Cyclin E2 mRNA levels peaks at the G1 / S transition. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27 (Kip1) and p21 (Cip1). Cyclin E2 / Cdk2 phosphorylates histone H1 in vitro. G1 cyclin E controls the initiation of DNA synthesis by activating CDK2. Abnormally high levels of cyclin E expression have frequently been observed in human cancers. Unlike Cyclin E1, which is expressed in great majority of proliferating normal and neoplastically transformed cells, Cyclin E2 levels are low to undetectable in non transformed cells and increase significantly in neoplasm derived cells.
  • Cellular localizationNuclear
  • Database links
  • Alternative names
    • CCN E2 antibody
    • CCNE 2 antibody
    • CCNE2 antibody
    • CCNE2 protein antibody
    • CYC E2 antibody
    • CYCE 2 antibody
    • CYCE2 antibody
    • CyclinE2 antibody
    • G1/S specific cyclin E2 antibody
    see all

Anti-Cyclin E2 antibody [EP454Y] images

  • Anti-Cyclin E2 antibody [EP454Y] (ab40890) at 1/2000 dilution + Jurkat cell lysate at 10 µg

    Predicted band size : 50 kDa
    Observed band size : 50 kDa
  • Immunofluorescent staining of staining HeLa cells using ab40890 (1/100).
  • ab40890 (1/250) staining human breast carcinoma by immunohistochemistry, paraffin-embedded tissue.

References for Anti-Cyclin E2 antibody [EP454Y] (ab40890)

This product has been referenced in:
  • Scharfmann R  et al. Development of a conditionally immortalized human pancreatic ß cell line. J Clin Invest 124:2087-98 (2014). WB ; Human . Read more (PubMed: 24667639) »
  • Lecona E  et al. Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes. PLoS Biol 11:e1001737 (2013). WB, IP ; Human . Read more (PubMed: 24358021) »

See all 9 Publications for this product

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