Anti-Cyclin E2 (phospho T392) antibody (ab111369)

Overview

  • Product nameAnti-Cyclin E2 (phospho T392) antibody
    See all Cyclin E2 primary antibodies
  • Description
    Rabbit polyclonal to Cyclin E2 (phospho T392)
  • Specificityab111369 Detects endogenous levels of Cyclin E2 only when phosphorylated at threonine 392.
  • Tested applicationsSuitable for: ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic phosphopeptide derived from Human Cyclin E2 around the phosphorylation site of threonine 392 (I-M-TP-P-P)

  • Positive control
    • NIH3T3 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab111369 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100 - 1/500.

Target

  • RelevanceThe human Cyclin E2 gene encodes a 404 amino acid protein that is most closely related to Cyclin E. Cyclin E2 mRNA levels peaks at the G1 / S transition. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27 (Kip1) and p21 (Cip1). Cyclin E2 / Cdk2 phosphorylates histone H1 in vitro. G1 cyclin E controls the initiation of DNA synthesis by activating CDK2. Abnormally high levels of cyclin E expression have frequently been observed in human cancers. Unlike Cyclin E1, which is expressed in great majority of proliferating normal and neoplastically transformed cells, Cyclin E2 levels are low to undetectable in non transformed cells and increase significantly in neoplasm derived cells.
  • Cellular localizationNuclear
  • Database links
  • Alternative names
    • CCN E2 antibody
    • CCNE 2 antibody
    • CCNE2 antibody
    • CCNE2 protein antibody
    • CYC E2 antibody
    • CYCE 2 antibody
    • CYCE2 antibody
    • CyclinE2 antibody
    • G1/S specific cyclin E2 antibody
    see all

Anti-Cyclin E2 (phospho T392) antibody images

  • ab111369 at 1/100 dilution staining Cyclin E2 in NIH3T3 cells by Immunofluorescence. The image on the right is treated with the synthesized phosphopeptide.

References for Anti-Cyclin E2 (phospho T392) antibody (ab111369)

ab111369 has not yet been referenced specifically in any publications.

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