Biological descriptionCell-permeable inhibitor of hedgehog (Hh) signaling, via direct inhibition of Smo (Smoothened), the accessory protein to the putative Hh receptor. Anticancer and teratogenic activity in vivo.
Chemical name(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a, 4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro- 3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'( 3'H)-furo[3,2-b]pyridin]-3-ol
Storage instructionsStore at -20°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 5 mM
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and
information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.