• Product nameAnti-Cyclophilin 40 antibody
    See all Cyclophilin 40 primary antibodies
  • Description
    Rabbit polyclonal to Cyclophilin 40
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Amphibians
  • Immunogen

    Recombinant full length protein corresponding to Human Cyclophilin 40. Expressed in E. coli.

  • Positive control
    • Rat brain extract.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.05% Sodium azide
    Constituent: 99% PBS
  • PurityWhole antiserum
  • Primary antibody notesImmunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents: cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. CyP-40, a 40 kDa protein, shares significant homology with smaller CyPA (CyP-18) and FKBP59. CyP-40 exhibits the characteristic CsA binding and isomerase activity of CyP-18, though these activities appear to be less with CyP-40 than with Cyp-18. Like FKBP59, CyP-40 has been found in progesterone receptor complexes. CyP-40 is expressed at similar levels in many tissues.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab5902 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 40 kDa (predicted molecular weight: 44 kDa).
EMSA Use at an assay dependent concentration.


  • FunctionPPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • Tissue specificityWidely expressed.
  • Sequence similaritiesBelongs to the cyclophilin-type PPIase family. PPIase D subfamily.
    Contains 1 PPIase cyclophilin-type domain.
    Contains 3 TPR repeats.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • 40 kDa peptidyl prolyl cis trans isomerase antibody
    • 40 kDa peptidyl prolyl cis trans isomerase D antibody
    • 40 kDa peptidyl-prolyl cis-trans isomerase antibody
    • Cyclophilin D antibody
    • Cyclophilin related protein antibody
    • Cyclophilin-40 antibody
    • Cyclophilin-related protein antibody
    • Cyclophilin40 antibody
    • CyclophilinD antibody
    • CYP 40 antibody
    • CYP-40 antibody
    • CYP40 antibody
    • CYPD antibody
    • MGC33096 antibody
    • Peptidyl Prolyl Isomerase D antibody
    • Peptidyl-prolyl cis-trans isomerase D antibody
    • Peptidylprolyl isomerase D antibody
    • PPIase antibody
    • PPIase D antibody
    • Ppid antibody
    • PPID_HUMAN antibody
    • Rotamase antibody
    • Rotamase D antibody
    see all

Anti-Cyclophilin 40 antibody images

  • Predicted band size : 44 kDa

    Western blot of Cyclophilin 40 on rat brain extract using ab5902.

References for Anti-Cyclophilin 40 antibody (ab5902)

This product has been referenced in:
  • Witting SR  et al. Helper-dependent adenovirus-mediated short hairpin RNA expression in the liver activates the interferon response. J Biol Chem 283:2120-8 (2008). WB ; Human . Read more (PubMed: 18025090) »

See 1 Publication for this product

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