The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
Use a concentration of 0.5 µg/ml. Predicted molecular weight: 24 kDa.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Involvement in disease
Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9) [MIM:259440]. OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients.
Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. Contains 1 PPIase cyclophilin-type domain.
Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Peptidyl prolyl cis trans isomerase B precursor antibody
Peptidyl-prolyl cis-trans isomerase B antibody
peptidylprolyl isomerase B (cyclophilin B) antibody
Peptidylprolyl isomerase B antibody
PPIase B antibody
Rotamase B antibody
S cyclophilin antibody
Western blot - Anti-Cyclophilin B antibody (ab171122)
Lanes 1 & 3 : Anti-Cyclophilin B antibody (ab171122) at 1/2000 dilution Lane 2 : Anti-Cyclophilin B antibody (ab171122) at 1/1000 dilution Lane 4 : Anti-Cyclophilin B antibody (ab171122) at 1/4000 dilution
Lane 1 : rat liver lysate Lane 2 : rat liver lysate Lane 3 : rat liver lysate Lane 4 : rat liver lysate