Cyclosporin A full length protein (ab73731)

Overview

  • Product nameCyclosporin A full length protein
  • DescriptionCyclosporin A full length protein

Description

  • NatureNatural
  • Amino Acid Sequence
    • SequenceChemically, cyclosporin is designated as [R-[R*,R*-(E)]]-cyclic(L-alanyl-D-alanyl-N-methyl- L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydr oxy-N, 4-dimethyl-L-2-amino-6-octenoyl-L-alpha-amino-buty ryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-met hyl-L-leucyl). Molecular Formula: C62H111N11O12.
    • Amino acids0 to 0

Specifications

Our Abpromise guarantee covers the use of ab73731 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None

  • ReconstitutionReconstitute the lyophilized Cyclosporin A in sterile 18Megaohm-cm H2O at not less than 100µg/ml, which can then be further diluted to other aqueous solutions

General info

  • RelevanceCyclosporin is used to prevent rejection following solid organ and bone marrow transplantation . It has been estimated that cyclosporine is given to more than 90% of children who have received a kidney transplant in the United States. In addition, the ability of cyclosporin to inhibit T-cell activation has been shown to have a role in the treatment of diseases such as nephrotic syndrome, refractory Crohn's disease and ulcerative colitis, biliary cirrhosis, aplastic anemia, rheumatoid arthritis, myasthenia gravis, and dermatomyositis.
  • Cellular localizationCytoplasmic

References for Cyclosporin A full length protein (ab73731)

ab73731 has not yet been referenced specifically in any publications.

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