• Product nameAnti-CYFIP1 antibody
    See all CYFIP1 primary antibodies
  • Description
    Rabbit polyclonal to CYFIP1
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Lizard, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residue 1203 and 1253 of Human CYFIP1 (NP_055423.1).

  • Positive control
    • HeLa and 293T whole cell lysates


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: Tris citrate/phosphate, pH 7-8
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab108220 was affinity purified using an epitope specific to CYFIP1 immobilized on solid support.
  • ClonalityPolyclonal
  • IsotypeIgG


Our Abpromise guarantee covers the use of ab108220 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 145 kDa.
IP Use at 2-5 µg/mg of lysate.


  • FunctionComponent of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
  • Sequence similaritiesBelongs to the CYFIP family.
  • Cellular localizationCytoplasm > perinuclear region. Cell projection > lamellipodium. Cell projection > ruffle. Cell junction > synapse > synaptosome. Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia.
  • Information by UniProt
  • Database links
  • Alternative names
    • CY antibody
    • CYFIP 1 antibody
    • CYFIP1 antibody
    • CYFP1_HUMAN antibody
    • Cytoplasmic FMR1 interacting protein 1 antibody
    • Cytoplasmic FMR1-interacting protein 1 antibody
    • FLJ45151 antibody
    • KIAA0068 antibody
    • p140sra 1 antibody
    • p140sra-1 antibody
    • P140SRA1 antibody
    • Selective hybridizing clone antibody
    • SHYC antibody
    • Specifically Rac1 associated protein 1 antibody
    • Specifically Rac1-associated protein 1 antibody
    • SRA 1 antibody
    • Sra-1 antibody
    • SRA1 antibody
    see all

Anti-CYFIP1 antibody images

  • All lanes : Anti-CYFIP1 antibody (ab108220) at 0.4 µg/ml

    Lane 1 : HeLa whole cell lysate at 50 µg
    Lane 2 : HeLa whole cell lysate at 15 µg
    Lane 3 : HeLa whole cell lysate at 5 µg
    Lane 4 : 293T whole cell lysate at 50 µg

    Developed using the ECL technique

    Predicted band size : 145 kDa

    Exposure time : 3 minutes
  • ab108220 at 1 µg/ml detecting CYFIP1 in HeLa whole cell lysate by WB following IP.

    Lane 1: IP with an antibody which recognizes an upstream epitope of CYFIP1
    Lane 2: ab108220 at 6 µg/mg of lysate
    Lane 3: Control IgG.

    In each case, 1 mg of lysate was used for IP and 20% of the IP was loaded.

    Detection: Chemiluminescence with an exposure time of 30 seconds

References for Anti-CYFIP1 antibody (ab108220)

ab108220 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your reply.

I appreciate the time you have spent on these experiments in the laboratory and it is disappointing the results have not been successful so far. As discussed in my previous email, although other antibodies in your la...

Read More

Thank you for taking time to complete our questionnaire. I am sorry to hear that this antibody is not providing satisfactory results.

The details provided will enable us to investigate this case and will provide us with vital information for...

Read More

Thank you for contacting us.

I am sorry to hear you are experiencing difficulties with one of our products. We take product complaints very seriously, and investigate every product that we feel may not be performing correctly.

I a...

Read More

Thank you for your enquiry.

All the products you have selected have been tested in human samples in western blot. If they have been specifically tested in human fibroblasts this would be stated on the product datasheet. I encourage you to ch...

Read More