Overview

  • Product name
  • Description
    Goat polyclonal to CYP26A1
  • Specificity
    ab107527 is expected to recognize both reported isoforms (NP_000774.2; NP_476498.1)
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-NLPARFTHFHGE

    , corresponding to internal sequence amino acids 485-496 of Human CYP26A1 (NP_000774.2; or 416-427 from NP_476498.1).

  • Positive control
    • Human cerebellum

Properties

Applications

Our Abpromise guarantee covers the use of ab107527 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 4 - 6 µg/ml. Recommended: steamed antigen retrieval with citrate buffer pH 6.

Target

  • Function
    Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
  • Tissue specificity
    Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.
  • Sequence similarities
    Belongs to the cytochrome P450 family.
  • Cellular localization
    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CP26 antibody
    • CP26A_HUMAN antibody
    • CYP26 antibody
    • CYP26A 1 antibody
    • cyp26a1 antibody
    • Cytochrome P450 26A1 antibody
    • Cytochrome P450 family 26 subfamily A polypeptide 1 antibody
    • Cytochrome P450 retinoic acid-inactivating 1 antibody
    • cytochrome P450, family 26, subfamily A, polypeptide 1 antibody
    • cytochrome P450, subfamily XXVIA, polypeptide 1 antibody
    • Cytochrome P450RAI antibody
    • hP450RAI antibody
    • OTTHUMP00000020102 antibody
    • OTTHUMP00000020103 antibody
    • P450 antibody
    • P450 retinoic acid inactivating 1 antibody
    • P450RAI antibody
    • P450RAI1 antibody
    • Retinoic acid 4 hydroxylase antibody
    • Retinoic acid 4-hydroxylase antibody
    • Retinoic acid metabolizing cytochrome antibody
    • Retinoic acid-metabolizing cytochrome antibody
    see all

Images

  • ab107527, at a concentration of 3.8 µg/ml, staining CYP26A1 in apparent adhesion sites between axons of paraffin embedded Human cerebellum by Immunohistochemistry. Steamed antigen retrieval with citrate buffer pH 6 and AP-staining were used.

References

ab107527 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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