Overview

  • Product name
  • Description
    Mouse polyclonal to CYP2C8
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human CYP2C8 (AAH20596.1, amino acids 1-490)

  • Positive control
    • Human liver tissue lysate; CYP2C8 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab88904 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 56 kDa.

Target

  • Function
    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
  • Sequence similarities
    Belongs to the cytochrome P450 family.
  • Cellular localization
    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CP2C8_HUMAN antibody
    • CPC8 antibody
    • CYP2C8 antibody
    • CYPIIC8 antibody
    • Cytochrome P450 2C8 antibody
    • Cytochrome P450 family 2 subfamily C polypeptide 8 antibody
    • Cytochrome P450 form 1 antibody
    • Cytochrome P450 IIC2 antibody
    • Cytochrome P450 MP-12 antibody
    • Cytochrome P450 MP-20 antibody
    • Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8 antibody
    • Flavoprotein linked monooxygenase antibody
    • Microsomal monooxygenase antibody
    • MP 12/MP 20 antibody
    • P450 form 1 antibody
    • P450 IIC2 antibody
    • P450 MP 12/MP 20 antibody
    • S mephenytoin 4 hydroxylase antibody
    • S-mephenytoin 4-hydroxylase antibody
    • Xenobiotic monooxygenase antibody
    see all

Images

  • Anti-CYP2C8 antibody (ab88904) at 1/500 dilution + human liver tissue lysate at 50 µg

    Predicted band size : 56 kDa
    Observed band size : 50 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-CYP2C8 antibody (ab88904) at 1/500 dilution

    Lane 1 : CYP2C8 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 56 kDa
    Observed band size : 48 kDa (why is the actual band size different from the predicted?)

References

ab88904 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you very much for your call today and for letting us know about the trouble with this antibody.

As we discussed, I'm sending a free of charge vial of ab126844 on the order ****. Please keep me updated about the results with this replace...

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Thank you for your enquiry.

Here is the peptide immunogeninformation for ab126844:

Synthetic peptide: KNVALTRSYIREK (Human) by a Cysteine residue linker from the internal region of Human CYP2C8 (NP_000761.3; NP_001185782.1; NP_00118...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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