Overview

  • Product name
  • Description
    Rabbit polyclonal to CYP2R1
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human CYP2R1 aa 152-180 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.

  • Positive control
    • NCI-H460 cell lysate Mouse liver tissue lysate

Applications

Our Abpromise guarantee covers the use of ab79924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/50 - 1/100. Detects a band of approximately 57 kDa (predicted molecular weight: 57 kDa).

Target

  • Function
    Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
  • Involvement in disease
    Defects in CYP2R1 are the cause of rickets vitamin D-dependent type 1B (VDDR1B) [MIM:600081]; also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. A disorder caused by a selective deficiency of the active form of vitamin D (1,25-dihydroxyvitamin D3) and resulting in defective bone mineralization and clinical features of rickets. The patients sera have low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activityand low levels of 25-hydroxyvitamin D.
  • Sequence similarities
    Belongs to the cytochrome P450 family.
  • Cellular localization
    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CP2R1_HUMAN antibody
    • CYP2R1 antibody
    • Cytochrome P450 2R1 antibody
    • Cytochrome P450 family 2 R1 antibody
    • Cytochrome P450 family 2 subfamily R polypeptide 1 antibody
    • EC 1.14.13.15 antibody
    • MGC4663 antibody
    • Vitamin D 25 hydroxylase antibody
    • Vitamin D 25-hydroxylase antibody
    see all

Anti-CYP2R1 antibody images

  • Anti-CYP2R1 antibody (ab79924) at 1/50 dilution + NCI-H460 cell lysate at 35 µg

    Predicted band size : 57 kDa
    Observed band size : 57 kDa
  • Anti-CYP2R1 antibody (ab79924) at 1/50 dilution + Mouse liver tissue lysate at 35 µg

    Predicted band size : 57 kDa
    Observed band size : 57 kDa

References for Anti-CYP2R1 antibody (ab79924)

ab79924 has not yet been referenced specifically in any publications.

Product Wall

This CYP2R1 antibody is generated from rabbits immunized with a KLH-conjugated synthetic peptide between 152-180 amino acids from the Central region of human CYP2R1.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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