Overview

  • Product nameCyproheptadine hydrochloride
  • Description
    Potent H1 and 5-HT2B antagonist. Non-selective receptor antagonist.
  • Biological descriptionPotent H1 and 5-HT2B antagonist (Ki and pKi values are 10 and 1.4 nM, respectively). Non-selective receptor antagonist (shows high potency (low nM) at other 5-HT, dopamine and muscarinic acetylcholine receptors. Displays antihistaminergic and antiserotonergic effects.
  • Purity> 99%

Properties

    References for Cyproheptadine hydrochloride (ab120732)

    This product has been referenced in:
    • Paoluzzi L  et al. The anti-histaminic cyproheptadine synergizes the antineoplastic activity of bortezomib in mantle cell lymphoma through its effects as a histone deacetylase inhibitor. Br J Haematol 146:656-9 (2009). Read more (PubMed: 19604235) »
    • Droogmans S  et al. Cyproheptadine prevents pergolide-induced valvulopathy in rats: an echocardiographic and histopathological study. Am J Physiol Heart Circ Physiol 296:H1940-8 (2009). Read more (PubMed: 19346455) »
    • Young R  et al. Pizotyline effectively attenuates the stimulus effects of N-methyl-3,4-methylenedioxyamphetamine (MDMA). Pharmacol Biochem Behav 82:404-10 (2005). Read more (PubMed: 16253319) »
    • Moguilevsky N  et al. Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene. Eur J Biochem 224:489-95 (1994). Read more (PubMed: 7925364) »

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