Overview

  • Product nameAnti-CysLT2 antibody
    See all CysLT2 primary antibodies
  • Description
    Rabbit polyclonal to CysLT2
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region from the 1st extracellular domain of Human CysLT2.

  • Positive control
    • Human Heart tissue

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab115453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionReceptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
  • Tissue specificityWidely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CLTR2_HUMAN antibody
    • CYSLT2 antibody
    • CYSLT2R antibody
    • CYSLTR 2 antibody
    • CysLTR2 antibody
    • Cysteinyl leukotriene CysLT2 receptor antibody
    • Cysteinyl leukotriene receptor 2 antibody
    • G protein coupled receptor antibody
    • G protein coupled receptor GPCR21 antibody
    • G protein coupled receptor HG57 antibody
    • G-protein coupled receptor GPCR21 antibody
    • G-protein coupled receptor HG57 antibody
    • GPCR antibody
    • HG57 antibody
    • hGPCR21 antibody
    • HPN321 antibody
    • PSEC0146 antibody
    see all

Anti-CysLT2 antibody images

  • ab115453, at 10 µg/ml, staining CysLT2 in formalin-fixed, paraffin-embedded Human Heart tissue by Immunohistochemistry, using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-CysLT2 antibody (ab115453)

This product has been referenced in:
  • Shirasaki H  et al. Localization and up-regulation of cysteinyl leukotriene-2 receptor in human allergic nasal mucosa. Allergol Int 62:223-8 (2013). IHC ; Human . Read more (PubMed: 23524649) »

See 1 Publication for this product

Product Wall

Application Immunocytochemistry/ Immunofluorescence
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C
Sample Mouse Cell (mouse/human retinal cross-sections)
Specification mouse/human retinal cross-sections
Permeabilization No
Fixative Paraformaldehyde
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Submitted Jan 13 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"