FunctionAs an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
Tissue specificityExpressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.
Involvement in diseaseAmyloidosis 6 Macular degeneration, age-related, 11
Sequence similaritiesBelongs to the cystatin family.
Post-translational modificationsThe Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21.
Amyloid angiopathy and cerebral hemorrhage antibody
bA218C14.4 (cystatin C) antibody
Cst 3 antibody
CST3 protein antibody
Cystatin 3 antibody
Gamma trace antibody
Neuroendocrine basic polypeptide antibody
Post gamma globulin antibody
Anti-Cystatin C antibody [MM0229-3N39] images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cystatin C antibody [MM0229-3N39] (ab97730)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placental tissue section (4µm) labelling CD239 Cystatin C ab97730. Tissue was treated with 15µg/ml Protenase K for antigen retrieval and fixed with 4% PFA. A HRP-conjugated anti-mouse IgG was used as the secondary antibody (30 minutes at room temperature) followed by DAB color development.
References for Anti-Cystatin C antibody [MM0229-3N39] (ab97730)
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