Cytochalasin D, actin polymerization inhibitor (ab143484)
Key features and details
- Potent actin polymerization inhibitor
- CAS Number: 22144-77-0
- Purity: > 98%
- Soluble in ethanol to 10 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Zygosporium mansonii
Overview
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Product name
Cytochalasin D, actin polymerization inhibitor -
Description
Potent actin polymerization inhibitor -
Purity
> 98% -
CAS Number
22144-77-0 -
Chemical structure
Properties
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Chemical name
(3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(Acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6-12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione -
Molecular weight
507.63 -
Molecular formula
C30H37NO6 -
PubChem identifier
5458428 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 10 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O -
Source
Zygosporium mansonii
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (15)
ab143484 has been referenced in 15 publications.
- Ran J et al. Targeting the HDAC6-Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity. Adv Sci (Weinh) 9:e2105365 (2022). PubMed: 35619548
- Kim HS et al. Förster Resonance Energy Transfer-Based Single-Cell Imaging Reveals Piezo1-Induced Ca2+ Flux Mediates Membrane Ruffling and Cell Survival. Front Cell Dev Biol 10:865056 (2022). PubMed: 35646889
- Cui Z et al. Altered pain sensitivity in 5×familial Alzheimer disease mice is associated with dendritic spine loss in anterior cingulate cortex pyramidal neurons. Pain 163:2138-2153 (2022). PubMed: 35384934
- Zhao Y et al. Focal adhesion regulates osteogenic differentiation of mesenchymal stem cells and osteoblasts. Biomater Transl 2:312-322 (2021). PubMed: 35837413
- Starostina I et al. Distinct calcium regulation of TRPM7 mechanosensitive channels at plasma membrane microdomains visualized by FRET-based single cell imaging. Sci Rep 11:17893 (2021). PubMed: 34504177