• Product nameAnti-Cytochrome C antibody
    See all Cytochrome C primary antibodies
  • Description
    Rabbit polyclonal to Cytochrome C
  • SpecificityThis antibody detects the 15 kDa cytochrome C.
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Chicken
  • Immunogen

    Synthetic peptide corresponding to residues surrounding amino acid 70 of rat Cytochrome C. (Peptide available as ab38265.)

  • Positive control
    • Jurkat cell lysate, NIH3T3 cell lysate and rat kidney tissue lysate.


Associated products


Our Abpromise guarantee covers the use of ab18738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 12 kDa.Can be blocked with Cytochrome C peptide (ab38265).
IP Use a concentration of 10 - 20 µg/ml.


  • FunctionElectron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
  • Involvement in diseaseDefects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
  • Sequence similaritiesBelongs to the cytochrome c family.
  • Post-translational
    Binds 1 heme group per subunit.
  • Cellular localizationMitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • CYC antibody
    • CYC_HUMAN antibody
    • CYCS antibody
    • Cytochrome c antibody
    • Cytochrome c somatic antibody
    • HCS antibody
    • THC4 antibody
    see all

References for Anti-Cytochrome C antibody (ab18738)

This product has been referenced in:
  • Dutta S  et al. The steroid hormone environment during primordial follicle formation in perinatal mouse ovaries. Biol Reprod 91:68 (2014). Mouse . Read more (PubMed: 25078683) »
  • Vucetic M  et al. Interscapular brown adipose tissue metabolic reprogramming during cold acclimation: Interplay of HIF-1a and AMPKa. Biochim Biophys Acta 1810:1252-61 (2011). Read more (PubMed: 21945600) »

See all 5 Publications for this product

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Thank you for your enquiry. I'm happy to report that the immunogen shares 100% homology with the sequence in chicken. I hope this information helps. Please do not hesitate to contact us if you need anything further.