Anti-Cytochrome C antibody [EP1326-80-5-4] (ab76237)

Overview

• Product nameAnti-Cytochrome C antibody [EP1326-80-5-4]
  See all Cytochrome C primary antibodies
• Description
  Rabbit monoclonal [EP1326-80-5-4] to Cytochrome C
• Tested applicationsSuitable for: WB, IP, IHC-P, ICCmore details
  Unsuitable for: Flow Cyt
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  A synthetic peptide corresponding to residues near the N-terminus of human Cytochrome C

• Positive control
  • HeLa mitochondrial lysate Human heart muscle tissue Human kidney tissue
• General notes

  This product is a recombinant rabbit monoclonal antibody.

   

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• PurityTissue culture supernatant
• ClonalityMonoclonal
• Clone numberEP1326-80-5-4
• IsotypeIgG
• Research areas
  • Cardiovascular
  • Lipids / Lipoproteins
  • Lipid Metabolism
  • Cytochromes

  • Cell Biology
  • Apoptosis
  • Mitochondrial

  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Signal Transduction
  • Metabolism
  • Mitochondrial

  • Cancer
  • Invasion/microenvironment
  • Apoptosis
  • Cytochrome C

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Integration of energy metabolism

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Oxidative phosphorylation

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipases

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Integration of energy

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Cytochromes

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Apoptosis

  • Metabolism
  • Types of disease
  • Cancer

  • Cancer
  • Cell Death
  • Apoptosis
  • Apoptotic Markers
  • Cytochrome C

  • Cancer
  • Cell Death
  • Apoptosis
  • Mitochondrial

  • Cancer
  • Cell Death
  • Apoptosis
  • Metabolism

Applications

Target

• FunctionElectron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
  Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
• Involvement in diseaseDefects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
• Sequence similaritiesBelongs to the cytochrome c family.
• Post-translational
  modificationsBinds 1 heme group per subunit.
• Cellular localizationMitochondrion matrix.

• Target information above from: UniProt accession P99999 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 54205 Human
  • Entrez Gene: 13063 Mouse
  • Entrez Gene: 25309 Rat
  • Omim: 123970 Human
  • SwissProt: P99999 Human
  • SwissProt: P62897 Mouse
  • SwissProt: P62898 Rat
  • Unigene: 437060 Human

  • Unigene: 617193 Human
  • Unigene: 35389 Mouse
  • Unigene: 2202 Rat

  see all
• Alternative names
  • CYC antibody
  • CYC_HUMAN antibody
  • CYCS antibody

  • Cytochrome c antibody
  • Cytochrome c somatic antibody
  • HCS antibody
  • THC4 antibody

  see all