Overview

Applications

Our Abpromise guarantee covers the use of ab54575 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 10 kDa.
IHC-P Use a concentration of 0.3 µg/ml.

Target

  • FunctionConnects the two COX monomers into the physiological dimeric form.
  • Involvement in diseaseDefects in COX6B1 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • Sequence similaritiesBelongs to the cytochrome c oxidase subunit 6B family.
  • Cellular localizationMitochondrion intermembrane space.
  • Information by UniProt
  • Database links
  • Alternative names
    • COX 6B antibody
    • COX VIb 1 antibody
    • COX VIb-1 antibody
    • COX6B antibody
    • COX6B1 antibody
    • COXG antibody
    • COXVIb1 antibody
    • CX6B1_HUMAN antibody
    • Cytochrome c oxidase subunit 6B1 antibody
    • Cytochrome c oxidase subunit VIb antibody
    • Cytochrome c oxidase subunit VIb isoform 1 antibody
    • cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) antibody
    • Cytochrome c oxidase subunit Vib polypeptide 1 antibody
    see all

Anti-Cytochrome C Oxidase subunit VIb antibody images



  • Predicted band size : 10 kDa
    Cytochrome C Oxidase subunit VIb antibody (ab54575) at 1ug/lane + HL-60 cell lysate at 25ug/lane.
  • ab54575 at 0.3 µg/ml staining Cytochrome C Oxidase subunit VIb in human kidney tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

References for Anti-Cytochrome C Oxidase subunit VIb antibody (ab54575)

This product has been referenced in:
  • Nuss JE  et al. Multi-Faceted Proteomic Characterization of Host Protein Complement of Rift Valley Fever Virus Virions and Identification of Specific Heat Shock Proteins, Including HSP90, as Important Viral Host Factors. PLoS One 9:e93483 (2014). WB . Read more (PubMed: 24809507) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"