Anti-Cyp26B1 antibody (ab113236)
Key features and details
- Rabbit polyclonal to Cyp26B1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Cyp26B1 antibody
See all Cyp26B1 primary antibodies -
Description
Rabbit polyclonal to Cyp26B1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant full length protein corresponding to Human Cyp26B1.
Database link: P450 26B -
Positive control
- Human Adrenal gland and Human brain, cerebellum tissues; HepG2 whole cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 79.99% Tris glycine -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab113236 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 58 kDa.
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IHC-P |
Use a concentration of 10 µg/ml.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 58 kDa. |
IHC-P
Use a concentration of 10 µg/ml. |
Target
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Function
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. -
Tissue specificity
Highly expressed in brain, particularly in the cerebellum and pons. -
Involvement in disease
Radiohumeral fusions with other skeletal and craniofacial anomalies -
Sequence similarities
Belongs to the cytochrome P450 family. -
Cellular localization
Endoplasmic reticulum membrane. Microsome membrane. - Information by UniProt
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Database links
- Entrez Gene: 56603 Human
- Entrez Gene: 232174 Mouse
- Entrez Gene: 312495 Rat
- Omim: 605207 Human
- SwissProt: Q9NR63 Human
- SwissProt: Q811W2 Mouse
- SwissProt: G3V7X8 Rat
- Unigene: 91546 Human
see all -
Alternative names
- CP26 antibody
- CP26B_HUMAN antibody
- CYP26A2 antibody
see all
Images
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ab113236, at 10µg/ml, staining Cyp26B1 in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry.
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ab113236, at 10µg/ml, staining Cyp26B1 in Formalin-fixed, Paraffin-embedded Human Brain cerebellum tissue by Immunohistochemistry.
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Anti-Cyp26B1 antibody (ab113236) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size: 58 kDa
7.5% SDS PAGE.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab113236 has been referenced in 1 publication.
- Mao S et al. A Schwann cell-enriched circular RNA circ-Ankib1 regulates Schwann cell proliferation following peripheral nerve injury. FASEB J 33:12409-12424 (2019). PubMed: 31415184