Anti-Cytochrome P450 26B antibody (ab53555)

Overview

  • Product nameAnti-Cytochrome P450 26B antibody
    See all Cytochrome P450 26B primary antibodies
  • Description
    Goat polyclonal to Cytochrome P450 26B
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog
  • Immunogen

    Synthetic peptide:

    C-SQARSEDKDGRFH

    , corresponding to internal sequence amino acids 418-430 of Human Cytochrome P450 26B

  • Positive control
    • Human Testis lysates and human cerebellum.

Properties

Applications

Our Abpromise guarantee covers the use of ab53555 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 4 - 6 µg/ml.

Target

  • FunctionInvolved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
  • Tissue specificityHighly expressed in brain, particularly in the cerebellum and pons.
  • Involvement in diseaseRadiohumeral fusions with other skeletal and craniofacial anomalies
  • Sequence similaritiesBelongs to the cytochrome P450 family.
  • Cellular localizationEndoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CP26 antibody
    • CP26B_HUMAN antibody
    • CYP26A2 antibody
    • cyp26b1 antibody
    • Cytochrome P450 26A2 antibody
    • Cytochrome P450 26B1 antibody
    • Cytochrome P450 family 26 subfamily B polypeptide 1 antibody
    • Cytochrome P450 retinoic acid-inactivating 2 antibody
    • Cytochrome P450 retinoid metabolizing protein antibody
    • Cytochrome P450 subfamily XXVIA, polypeptide 2 antibody
    • Cytochrome P450 subfamily XXVIB polypeptide 1 antibody
    • Cytochrome P450RAI-2 antibody
    • DKFZp686G0638 antibody
    • dol antibody
    • EC 1.14. antibody
    • fc21d03 antibody
    • MGC129613 antibody
    • P450 26A2 antibody
    • P450 retinoic acid inactivating 2 antibody
    • P450RAI 2 antibody
    • P450RAI2 antibody
    • Retinoic acid metabolizing cytochrome antibody
    • Retinoic acid-metabolizing cytochrome antibody
    • RHFCA antibody
    • stocksteif antibody
    • wu:fc21d03 antibody
    • wu:fc26h10 antibody
    • zgc:76999 antibody
    see all

Anti-Cytochrome P450 26B antibody images

  • ab53555 at 4µg/ml staining Cytochrome P450 26B in Human cerebellum by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with Tris/EDTA buffer pH 9 was performed. Antibody was detected by HRP-staining.

References for Anti-Cytochrome P450 26B antibody (ab53555)

ab53555 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab53555.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"