Overview

  • Product nameAnti-Cytochrome P450 2D6 antibody
    See all Cytochrome P450 2D6 primary antibodies
  • Description
    Rabbit polyclonal to Cytochrome P450 2D6
  • SpecificityRecognizes P450 2D6 in human liver microsomes.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human) expressed in E. coli.

Properties

Applications

Our Abpromise guarantee covers the use of ab4238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: 1/1000 (positive control 0.2 µg of recombinant human cytochrome P450 2D6). Predicted molecular weight: 60 kDa.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceCytochrome P450 2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1).
    • Cellular localizationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
    • Database links
    • Alternative names
      • CPD6 antibody
      • CYP2D antibody
      • CYP2D6 antibody
      • CYP2D7AP antibody
      • CYP2D7BP antibody
      • CYP2D7P2 antibody
      • CYP2D8P2 antibody
      • CYP2DL1 antibody
      • CYPIID6 antibody
      • Cytochrome P450 DB1 antibody
      • Cytochrome P450 family 2 subfamily D polypeptide 6 antibody
      • Debrisoquine 4 hydroxylase antibody
      • Flavoprotein linked monooxygenase antibody
      • Microsomal monooxygenase antibody
      • P450 DB1 antibody
      • P450C2D antibody
      • P450DB1 antibody
      • Xenobiotic monooxygenase antibody
      see all

    References for Anti-Cytochrome P450 2D6 antibody (ab4238)

    This product has been referenced in:
    • DiMaio Knych HK & Stanley SD Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. Biochem Pharmacol 76:904-11 (2008). Read more (PubMed: 18692486) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"