Anti-Cytochrome P450 2D6 antibody (ab76627)

Overview

  • Product nameAnti-Cytochrome P450 2D6 antibody
    See all Cytochrome P450 2D6 primary antibodies
  • Description
    Mouse monoclonal to Cytochrome P450 2D6
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey
  • Immunogen

    Recombinant fragment: LVTHGEDTAD RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFANHSGR PFRPNGLLDK AVSNVIASLT, corresponding to amino acids 91-190 of Human Cytochrome P450 2D6, with tag.

  • Positive control
    • K-562 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab76627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration. Detection limit for recombinant tagged Cytochrome P450 2D6 is approximately 3ng/ml if used as a capture antibody.

Target

  • RelevanceCytochrome P450 2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1).
  • Cellular localizationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • Database links
  • Alternative names
    • CPD6 antibody
    • CYP2D antibody
    • CYP2D6 antibody
    • CYP2D7AP antibody
    • CYP2D7BP antibody
    • CYP2D7P2 antibody
    • CYP2D8P2 antibody
    • CYP2DL1 antibody
    • CYPIID6 antibody
    • Cytochrome P450 DB1 antibody
    • Cytochrome P450 family 2 subfamily D polypeptide 6 antibody
    • Debrisoquine 4 hydroxylase antibody
    • Flavoprotein linked monooxygenase antibody
    • Microsomal monooxygenase antibody
    • P450 DB1 antibody
    • P450C2D antibody
    • P450DB1 antibody
    • Xenobiotic monooxygenase antibody
    see all

References for Anti-Cytochrome P450 2D6 antibody (ab76627)

ab76627 has not yet been referenced specifically in any publications.

Product Wall

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Read More
Abcam has not validated the combination of species/application used in this Abreview.
Application Western blot
Sample Monkey Tissue lysate - nuclear (Cyno monkey liver)
Loading amount 40 µg
Specification Cyno monkey liver
Gel Running Conditions Reduced Denaturing
Blocking step Odyssey Blocker as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 100% · Temperature: 22°C
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Submitted Jul 23 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"