Anti-Cytochrome P450 2D6 antibody (ab98137)

Overview

  • Product nameAnti-Cytochrome P450 2D6 antibody
    See all Cytochrome P450 2D6 primary antibodies
  • Description
    Rabbit polyclonal to Cytochrome P450 2D6
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids 431-480 (EAFLPFSAGR RACLGEPLAR MELFLFFTSL LQHFSFSVPT GQPRPSHHGV) of Human Cytochrome P450 2D6 (NP_000097).

  • Positive control
    • OVCAR3 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab98137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 56 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceCytochrome P450 2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1).
  • Cellular localizationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • Database links
  • Alternative names
    • CPD6 antibody
    • CYP2D antibody
    • CYP2D6 antibody
    • CYP2D7AP antibody
    • CYP2D7BP antibody
    • CYP2D7P2 antibody
    • CYP2D8P2 antibody
    • CYP2DL1 antibody
    • CYPIID6 antibody
    • Cytochrome P450 DB1 antibody
    • Cytochrome P450 family 2 subfamily D polypeptide 6 antibody
    • Debrisoquine 4 hydroxylase antibody
    • Flavoprotein linked monooxygenase antibody
    • Microsomal monooxygenase antibody
    • P450 DB1 antibody
    • P450C2D antibody
    • P450DB1 antibody
    • Xenobiotic monooxygenase antibody
    see all

Anti-Cytochrome P450 2D6 antibody images

  • Anti-Cytochrome P450 2D6 antibody (ab98137) at 1 µg/ml (in 5% skim milk / PBS buffer) + OVCAR3 cell lysate at 10 µg

    Predicted band size : 56 kDa

References for Anti-Cytochrome P450 2D6 antibody (ab98137)

ab98137 has not yet been referenced specifically in any publications.

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