Anti-Cytochrome P450 Reductase antibody (ab106255)

Overview

  • Product nameAnti-Cytochrome P450 Reductase antibody
    See all Cytochrome P450 Reductase primary antibodies
  • Description
    Goat polyclonal to Cytochrome P450 Reductase
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Rabbit, Guinea pig, Cow, Dog, Pig, Xenopus laevis, Chinese Hamster
  • Immunogen

    Synthetic peptide:

    C-TNPPRTNVLYE

    , corresponding to internal sequence amino acids 381-391 of Human Cytochrome P450 Reductase (NP_000932.3).

  • Positive control
    • Human, Mouse and Rat Liver lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab106255 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 77 kDa).

Target

  • FunctionThis enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
  • Involvement in diseaseDefects in POR are the cause of adrenal hyperplasia variant type (AHV) [MIM:201750]; also known as Antley-Bixler syndrome-like phenotype with disordered steroidogenesis. AHV is a rare variant of congenital adrenal hyperplasia. It is an autosomal recessive disorder with apparent combined P450C17 and P450C21 deficiency. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can also present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
    Defects in POR are a cause of isolated disordered steroidogenesis (IDS) [MIM:201750].
  • Sequence similaritiesIn the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
    Contains 1 FAD-binding FR-type domain.
    Contains 1 flavodoxin-like domain.
  • Cellular localizationEndoplasmic reticulum membrane. Anchored to the ER membrane by its N-terminal hydrophobic region.
  • Information by UniProt
  • Database links
  • Alternative names
    • CPR antibody
    • CYPOR antibody
    • DKFZp686G04235 antibody
    • FLJ26468 antibody
    • NADPH Cytochrome P450 Reductase antibody
    • NADPH dependent cytochrome P450 reductase antibody
    • NADPH--cytochrome P450 reductase antibody
    • NCPR_HUMAN antibody
    • P450 (cytochrome) oxidoreductase antibody
    • P450 Cytochrome Oxidoreductase antibody
    • P450R antibody
    • por antibody
    see all

Anti-Cytochrome P450 Reductase antibody images

  • Anti-Cytochrome P450 Reductase antibody (ab106255) at 0.1 µg/ml + Rat Liver lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 77 kDa

References for Anti-Cytochrome P450 Reductase antibody (ab106255)

ab106255 has not yet been referenced specifically in any publications.

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