Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab151219 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 47 kDa.
IP Use at an assay dependent dilution.

Target

  • Function
    Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 1 PH domain.
    Contains 1 SEC7 domain.
  • Domain
    The PH domain is necessary and sufficient for plasma membrane relocalization.
  • Cellular localization
    Cell membrane. Cytoplasm. Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. Requires also interaction with phosphoinositides for targeting to plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ARF exchange factor antibody
    • ARF nucleotide binding site opener antibody
    • ARF nucleotide-binding site opener antibody
    • Arno antibody
    • ARNO protein antibody
    • CLM2 antibody
    • CTS18 antibody
    • CTS18.1 antibody
    • CYH2_HUMAN antibody
    • Cyth2 antibody
    • Cytohesin 2 antibody
    • Cytohesin-2 antibody
    • MGC137537 antibody
    • MGC80440 antibody
    • PH antibody
    • PH, SEC7 and coiled-coil domain-containing protein 2 antibody
    • Pleckstrin homology Sec7 and coiled coil domains 2 antibody
    • Pleckstrin homology Sec7 and coiled coil domains protein 2 antibody
    • Protein ARNO antibody
    • PSCD2 antibody
    • PSCD2L antibody
    • PSCD2L, formerly antibody
    • SEC7 and coiled-coil domain-containing protein 2 antibody
    • Sec7 antibody
    • SEC7 homolog B antibody
    • Sec7B antibody
    • SEC7L antibody
    • Sec7p L antibody
    • Sec7p-like antibody
    • Sec7pL antibody
    see all

References

ab151219 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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