Anti-Cytokeratin 10 antibody [DE-K10] (ab80523)

Overview

  • Product nameAnti-Cytokeratin 10 antibody [DE-K10]See all Cytokeratin 10 primary antibodies ...
  • Description
    Mouse monoclonal [DE-K10] to Cytokeratin 10
  • Tested applicationsWB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Rat, Cat, Dog, Human
  • Immunogen

    Cytoskeletal preparation extracted from Human ectocervical epithelium.

  • Positive control
    • A431 cells. Skin.

Properties

Applications

Our Abpromise guarantee covers the use of ab80523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
ICC/IF
  • Application notesICC/IF: Use at an assay dependent dilution.
    IHC-P: Use at a concentration of 0.5 - 1 µg/ml. Antigen retrieval is not required.
    WB: Use at a concentration of 1 - 2 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Tissue specificitySeen in all suprabasal cell layers including stratum corneum.
    • Involvement in diseaseDefects in KRT10 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
      Defects in KRT10 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
    • Sequence similaritiesBelongs to the intermediate filament family.
    • Information by UniProt
    • Database links
    • Alternative names
      • 56 kDa cytokeratin antibody
      • BCIE antibody
      • BIE antibody
      • CK 10 antibody
      • CK-10 antibody
      • ck10 antibody
      • Cytokeratin 10 antibody
      • Cytokeratin 6B antibody
      • Cytokeratin VIB antibody
      • Cytokeratin-10 antibody
      • Cytokeratin10 antibody
      • EHK antibody
      • k10 antibody
      • K1C10_HUMAN antibody
      • Keratin 10 antibody
      • Keratin antibody
      • Keratin type i cytoskeletal 10 antibody
      • Keratin type I cytoskeletal 59 kDa antibody
      • Keratin-10 antibody
      • Keratin10 antibody
      • kpp antibody
      • Krt 1 10 antibody
      • Krt 10 antibody
      • KRT10 antibody
      • krt10  antibody
      • type I cytoskeletal 10 antibody
      • Type I keratin Ka10 antibody
      see all

    Anti-Cytokeratin 10 antibody [DE-K10] images

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human skin tissue using 1µg/ml ab80519 in with a peroxidase-conjugated secondary antibody and an AEC chromogen. Note cytoplasmic staining of epidermal region.
    • Anti-Cytokeratin 10 antibody [DE-K10] (ab80523) at 2 µg/ml + A431 cell lysate

      Predicted band size : 60 kDa
      Observed band size : 60 kDa

    References for Anti-Cytokeratin 10 antibody [DE-K10] (ab80523)

    ab80523 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab80523.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"