Anti-Cytokeratin 13 antibody - C-terminal (ab188874)

Overview

  • Product name
    Anti-Cytokeratin 13 antibody - C-terminal
    See all Cytokeratin 13 primary antibodies
  • Description
    Goat polyclonal to Cytokeratin 13 - C-terminal
  • Host species
    Goat
  • Specificity
    ab188874 is expected to recognize the reported isoform a (NP_002265.2) only.
  • Tested applications
    Suitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human Cytokeratin 13 aa 444-458 (C terminal) (Cysteine residue).
    Sequence:

    TSNASGRRTSDVRRP


    Database link: P13646

  • Positive control
    • Human lung lysate and human tonsil tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab188874 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 0.1 - 0.3 µg/ml.
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 50 kDa.
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • Tissue specificity
    Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.
  • Involvement in disease
    Defects in KRT13 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
  • Sequence similarities
    Belongs to the intermediate filament family.
  • Post-translational
    modifications
    O-glycosylated; glycans consist of single N-acetylglucosamine residues.
  • Information by UniProt
  • Database links
  • Alternative names
    • 47 kDa cytokeratin antibody
    • CK-13 antibody
    • CK13 antibody
    • Cytokeratin 13 antibody
    • Cytokeratin-13 antibody
    • K13 antibody
    • K1C13_HUMAN antibody
    • Ka13 antibody
    • Keratin 13 antibody
    • Keratin antibody
    • keratin type I cytoskeletal 13 antibody
    • Keratin-13 antibody
    • Krt-1.13 antibody
    • Krt1-13 antibody
    • KRT13 antibody
    • MGC161462 antibody
    • MGC3781 antibody
    • type I cytoskeletal 13 antibody
    • Type I keratin Ka13 antibody
    • WSN2 antibody
    see all

Images

  • Anti-Cytokeratin 13 antibody - C-terminal (ab188874) at 0.1 µg/ml + Human lung lysate (in RIPA buffer) at 35 µg

    Predicted band size: 50 kDa

  • Immunohistochemical analysis of paraffin embedded human tonsil tissue labeling Cytokeratin 13 with ab188874 at 2.5 µg/ml.

References

ab188874 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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