Anti-Cytokeratin 16 antibody [SPM264], prediluted (ab25820)

Overview

  • Product nameAnti-Cytokeratin 16 antibody [SPM264], prediluted
    See all Cytokeratin 16 primary antibodies
  • Description
    Mouse monoclonal [SPM264] to Cytokeratin 16, prediluted
  • Specificityab25820 recognises cytokeratin 16. We have data to indicate that this antibody may not cross react with Rat. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide from the C-terminus of cytokeratin 16. (Human)

  • Positive control
    • Squamous cell carcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab25820 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: Ready-to-use (2ug/ml) for 30 min at RT Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Tissue specificityExpressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.
    • Involvement in diseaseDefects in KRT16 are a cause of pachyonychia congenita type 1 (PC1) [MIM:167200]; also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.
      Defects in KRT16 are the cause of palmoplantar keratoderma non-epidermolytic focal (FNEPPK) [MIM:613000]. A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present.
      Defects in KRT16 are a cause of unilateral palmoplantar verrucous nevus (UPVN) [MIM:144200]. UPVN is characterized by a localized thickening of the skin in parts of the right palm and the right sole.
      Note=KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
    • Sequence similaritiesBelongs to the intermediate filament family.
    • Information by UniProt
    • Database links
    • Alternative names
      • CK 16 antibody
      • CK-16 antibody
      • CK16 antibody
      • Cytokeratin-16 antibody
      • Cytokeratin16 antibody
      • FNEPPK antibody
      • Focal non epidermolytic palmoplantar keratoderma antibody
      • K 16 antibody
      • K16 antibody
      • K1C16_HUMAN antibody
      • K1CP antibody
      • Keratin 1 type I antibody
      • Keratin 16 antibody
      • Keratin antibody
      • Keratin type I cytoskeletal 16 antibody
      • Keratin-16 antibody
      • Keratin16 antibody
      • KRT 16 antibody
      • Krt16 antibody
      • KRT16A antibody
      • NEPPK antibody
      • PC1 antibody
      • type I cytoskeletal 16 antibody
      see all

    Anti-Cytokeratin 16 antibody [SPM264], prediluted images

    • ab25820, undiluted staining human cytokeratin 16 in squamous cell carcinoma by Immunohistochemistry, Formalin fixed Paraffin embedded tissue.

    References for Anti-Cytokeratin 16 antibody [SPM264], prediluted (ab25820)

    ab25820 has not yet been referenced specifically in any publications.

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    Thank you for your enquiry. I have received a reply from the originators of ab18586 and ab25820. The concentration ab18586 is 5mg/ml and the concentration of ab25820 is 2ug/ml. Please don't hesitate to contact us again if you have further questi...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"