Anti-Cytokeratin 19 antibody [RCK108], prediluted (ab49912)

Overview

  • Product nameAnti-Cytokeratin 19 antibody [RCK108], prediluted
    See all Cytokeratin 19 primary antibodies
  • Description
    Mouse monoclonal [RCK108] to Cytokeratin 19, prediluted
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Tissue/ cell preparation (Human), Cell line T24

  • Positive control
    • Glandular epithelia
  • General notes


    This antibody stains practically all epithelial tumours, especially adenocarcinoma. Staining is negative in hepatocellular carcinoma and also in most medullary and weakly differentiated ductal carcinomas.

Properties

  • FormPrediluted
  • Storage instructionsShipped at 4°C. Store at +4°C.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: Phosphate buffer, pH 7.3
  • Concentration information loading...
  • PurityTissue culture supernatant
  • Primary antibody notesThis antibody stains practically all epithelial tumours, especially adenocarcinoma. Staining is negative in hepatocellular carcinoma and also in most medullary and weakly differentiated ductal carcinomas.
  • ClonalityMonoclonal
  • Clone numberRCK108
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab49912 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Use Neat, 100µl per test.

WB Use at an assay dependent concentration. Detects a band of approximately 40 kDa (predicted molecular weight: 48 kDa).

Target

  • FunctionInvolved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
  • Tissue specificityExpressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
  • Sequence similaritiesBelongs to the intermediate filament family.
  • Developmental stagePresent in hair follicles at all stages of development.
  • DomainThis keratin differs from all other IF proteins in lacking the C-terminal tail domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • 40 kDa keratin intermediate filament antibody
    • CK 19 antibody
    • CK-19 antibody
    • CK19 antibody
    • Cytokeratin 19 antibody
    • Cytokeratin-19 antibody
    • K19 antibody
    • K1C19_HUMAN antibody
    • K1CS antibody
    • Keratin 19 antibody
    • Keratin type I 40 kD antibody
    • Keratin type I 40kD antibody
    • Keratin type I cytoskeletal 19 antibody
    • Keratin, type I cytoskeletal 19 antibody
    • Keratin, type I, 40 kd antibody
    • Keratin-19 antibody
    • KRT19 antibody
    • MGC15366 antibody
    see all

References for Anti-Cytokeratin 19 antibody [RCK108], prediluted (ab49912)

ab49912 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"