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Function
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.
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Tissue specificity
Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
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Sequence similarities
Belongs to the intermediate filament family.
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Developmental stage
First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as well as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative.
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Post-translational
modifications
Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury.
Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.
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Cellular localization
Cytoplasm.
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Information by UniProt
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Database links
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Alternative names
- CD20 antibody
- CK 20 antibody
- CK-20 antibody
- CK20 antibody
- Cytokeratin-20 antibody
- Cytokeratin20 antibody
- K1C20_HUMAN antibody
- K20 antibody
- KA20 antibody
- Keratin 20 antibody
- keratin 20, type I antibody
- keratin 21, rat, homolog of antibody
- Keratin antibody
- Keratin type I cytoskeletal 20 antibody
- Keratin-20 antibody
- Keratin20 antibody
- KRT 20 antibody
- KRT 21 antibody
- KRT20 antibody
- KRT21 antibody
- MGC35423 antibody
- OTTHUMP00000164518 antibody
- Protein IT antibody
- type I cytoskeletal 20 antibody
see all