• Product nameAnti-Cytokeratin 4 antibody
    See all Cytokeratin 4 primary antibodies
  • Description
    Rabbit polyclonal to Cytokeratin 4
  • Tested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
    Does not react with: Mouse
  • Immunogen

    Synthetic peptide corresponding to residues near the N terminal of human Cytokeratin 4.

  • Positive control
    • A431 cell lysate and human transitional bladder carcinoma.



Our Abpromise guarantee covers the use of ab51600 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100 - 1/250.
WB 1/2000. Detects a band of approximately 59 kDa (predicted molecular weight: 57 kDa).
IHC-P Use at an assay dependent concentration.


  • Tissue specificityDetected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
  • Involvement in diseaseDefects in KRT4 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
  • Sequence similaritiesBelongs to the intermediate filament family.
  • Information by UniProt
  • Database links
  • FormLocalisation: Intermediate filament (Cytoskeleton).
  • Alternative names
    • CK 4 antibody
    • CK-4 antibody
    • CK4 antibody
    • CYK4 antibody
    • Cytokeratin 4 antibody
    • Cytokeratin-4 antibody
    • Cytokeratin4 antibody
    • FLJ31692 antibody
    • K2C4_HUMAN antibody
    • K4 antibody
    • Keratin 4 antibody
    • Keratin antibody
    • Keratin type II cytoskeletal 4 antibody
    • Keratin-4 antibody
    • Keratin4 antibody
    • KRT 4 antibody
    • Krt4 antibody
    • type II cytoskeletal 4 antibody
    • Type-II keratin Kb4 antibody
    see all

Anti-Cytokeratin 4 antibody images

  • Anti-Cytokeratin 4 antibody (ab51600) at 1/2000 dilution + A431 cell lysate at 10 µg

    Goat anti-Rabbit HRP at 1/2000 dilution

    Predicted band size : 57 kDa
    Observed band size : 59 kDa (why is the actual band size different from the predicted?)
  • Immunohistochemical analysis of paraffin embedded human transitional bladder carcinoma using ab51600 (1/100). Secondary staining with Goat anti-Rabbit HRP (1/2000).

References for Anti-Cytokeratin 4 antibody (ab51600)

This product has been referenced in:
  • Tabuchi Y  et al. Development of oral epithelial cell line ROE2 with differentiation potential from transgenic rats harboring temperature-sensitive simian virus40 large T-antigen gene. Exp Anim 63:31-44 (2014). WB ; Rat . Read more (PubMed: 24521861) »
  • Vincent-Bugnas S  et al. EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis. PLoS One 8:e80336 (2013). IHC-P ; Human . Read more (PubMed: 24367478) »

See all 3 Publications for this product

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