• Product nameAnti-Cytokeratin 7+17 antibody [C-46]
  • Description
    Mouse monoclonal [C-46] to Cytokeratin 7+17
  • SpecificityCytokeratin peptides 7 (54 kDa) and 17 (46 kDa)
  • Tested applicationsSuitable for: ICC, WB, IHC-P, IPmore details
  • Species reactivity
    Reacts with: Sheep, Cow, Dog, Human, Pig
    Does not react with: Mouse, Rat, Rabbit
  • Immunogen

    Tissue/ cell preparation (Human). (Cytoskeleton preparation of HeLa cells (cervix carcinoma)).

  • General notesStrongly positive on most simple epithelia except for stomach, small intestine and colon mucosa, hepatocytes, pancreatic acini, renal tubules, also positive on some non-cornifying epithelia.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 15mM Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • Purity>95% by SDS-PAGE
  • Purification notesPurified from culture supernatant using protein A-affinity chromatography.
  • ClonalityMonoclonal
  • Clone numberC-46
  • IsotypeIgG1
  • Research areas


Our Abpromise guarantee covers the use of ab670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesICC: Use at an assay dependant concentration.
    IHC-P: Use at an assay dependant dilution. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.
    IP: Use at an assay dependant dilution.
    WB: Use at an assay dependant concentration.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceCytokeratin 7 and 17 is a heterotetramer of a type I and type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7. Cytokeratin 7 blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Cytokeratin 17 is required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling.
    • Cellular localizationCytoplasmic
    • Database links
    • Alternative names
      • CK17 antibody
      • CK7 antibody
      • Cytokeratin 17 antibody
      • Cytokeratin 7 antibody
      • K17 antibody
      • K7 antibody
      • Keratin 17 antibody
      • Keratin 7 antibody
      • KRT17 antibody
      • KRT7 antibody
      see all

    Anti-Cytokeratin 7+17 antibody [C-46] images

    • Anti-Cytokeratin 7+17 antibody [C-46] (ab670) at 1 µg/ml + HeLa cell lysate

      Observed band size : 49,51 kDa (why is the actual band size different from the predicted?)
    • Ab670 (20ug/ml) staining human Cytokeratin 7+17 in human pancreas by immunohistochemistry using formalin fixed, paraffin embedded tissue.

    References for Anti-Cytokeratin 7+17 antibody [C-46] (ab670)

    This product has been referenced in:
    • Sun Y  et al. Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis. Toxicology 262:162-70 (2009). Read more (PubMed: 19524636) »
    • Vojtesek B  et al. A panel of monoclonal antibodies to keratin no. 7: characterization and value in tumor diagnosis. Neoplasma 37:333-42 (1990). Read more (PubMed: 1695327) »

    See all 2 Publications for this product

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