Overview

  • Product name
    Anti-Cytokeratin 8 antibody [KS8.7]
    See all Cytokeratin 8 primary antibodies
  • Description
    Mouse monoclonal [KS8.7] to Cytokeratin 8
  • Host species
    Mouse
  • Specificity
    ab182875 reacts with MCF7, RT 112 and PLC cells as well as with adeno-carcinomas, undifferentiated carcinomas, cervix carcinomas and hepatocellular carcinomas.
  • Tested applications
    Suitable for: IHC-Fr, IHC-P, ICC, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Hamster, Human, Pig
  • Immunogen

    Tissue, cells or virus corresponding to Human Cytokeratin 8. Cultured HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab182875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.
ICC Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 53 kDa.

Target

  • Function
    Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
  • Tissue specificity
    Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
  • Involvement in disease
    Cirrhosis
  • Sequence similarities
    Belongs to the intermediate filament family.
  • Post-translational
    modifications
    Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
    O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.
    O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Cellular localization
    Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • CARD2 antibody
    • CK 8 antibody
    • CK-8 antibody
    • CK8 antibody
    • CYK8 antibody
    • CYKER antibody
    • Cytokeratin endo A antibody
    • Cytokeratin-8 antibody
    • DreK8 antibody
    • EndoA antibody
    • K2C8 antibody
    • K2C8_HUMAN antibody
    • K8 antibody
    • Keratin 8 antibody
    • Keratin type II cytoskeletal 8 antibody
    • Keratin, type II cytoskeletal 8 antibody
    • Keratin-8 antibody
    • KO antibody
    • Krt 2.8 antibody
    • KRT8 antibody
    • MGC118110 antibody
    • MGC174782 antibody
    • MGC53564 antibody
    • MGC85764 antibody
    • sb:cb186 antibody
    • Type-II keratin Kb8 antibody
    see all

References

This product has been referenced in:
  • Uemura KI  et al. Subcutaneous transplantation promotes organ formation of the fetal rat urogenital sinus. Acta Histochem N/A:N/A (2015). Read more (PubMed: 25858530) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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