Anti-Cytokeratin antibody [CK 210 and CK 211 (AE1+AE3] (ab115963)

Overview

  • Product name
    Anti-Cytokeratin antibody [CK 210 and CK 211 (AE1+AE3]
    See all Cytokeratin primary antibodies
  • Description
    Mouse monoclonal [CK 210 and CK 211 (AE1+AE3] to Cytokeratin
  • Tested applications
    Suitable for: IHC-P, IHC-Fr, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Rabbit, Chicken, Cow, Human, Pig, Monkey
  • Immunogen

    Full length native protein (purified) corresponding to Human Cytokeratin.

  • Positive control
    • Human skin, lung carcinoma tissues.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.40
    Preservative: 0.05% Sodium azide
    Constituents: 98% PBS, 1% BSA
  • Concentration information loading...
  • Purity
    Ascites
  • Clonality
    Monoclonal
  • Clone number
    CK 210 and CK 211 (AE1+AE3
  • Isotype
    IgG1
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab115963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. An antigen retriever like trypsin is required.
IHC-Fr 1/50 - 1/100.
ICC Use at an assay dependent concentration.

Target

  • Function
    May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1).
  • Tissue specificity
    The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.
  • Involvement in disease
    Defects in KRT1 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
    Defects in KRT1 are the cause of ichthyosis hystrix Curth-Macklin type (IHCM) [MIM:146590]. IHCM is a genodermatosis with severe verrucous hyperkeratosis. Affected individuals manifest congenital verrucous black scale on the scalp, neck, and limbs with truncal erythema, palmoplantar keratoderma and keratoses on the lips, ears, nipples and buttocks.
    Defects in KRT1 are a cause of palmoplantar keratoderma non-epidermolytic (NEPPK) [MIM:600962]. NEPKK is a dermatological disorder characterized by focal palmoplantar keratoderma with oral, genital, and follicular lesions.
    Defects in KRT1 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
    Defects in KRT1 are the cause of palmoplantar keratoderma striate type 3 (SPPK3) [MIM:607654]; also known as keratosis palmoplantaris striata III. SPPK3 is a dermatological disorder affecting palm and sole skin where stratum corneum and epidermal layers are thickened. There is no involvement of non-palmoplantar skin, and both hair and nails are normal.
  • Sequence similarities
    Belongs to the intermediate filament family.
  • Post-translational
    modifications
    Undergoes deimination of some arginine residues (citrullination).
  • Cellular localization
    Cell membrane. Located on plasma membrane of neuroblastoma NMB7 cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • 67 kDa cytokeratin antibody
    • CK-1 antibody
    • CK1 antibody
    • Cytokeratin 1 antibody
    • Cytokeratin 19 antibody
    • Cytokeratin 8 antibody
    • Cytokeratin-1 antibody
    • EHK antibody
    • EHK1 antibody
    • epidermolytic hyperkeratosis 1 antibody
    • EPPK antibody
    • Hair alpha protein antibody
    • K1 antibody
    • K2C1_HUMAN antibody
    • KB1 antibody
    • Keratin 1 antibody
    • keratin 1, type II antibody
    • Keratin 19 antibody
    • Keratin 8 antibody
    • Keratin antibody
    • keratin, type II cytoskeletal 1 antibody
    • Keratin-1 antibody
    • Krt1 antibody
    • KRT19 antibody
    • KRT1A antibody
    • KRT8 antibody
    • KRTA antibody
    • NEPPK antibody
    • type II cytoskeletal 1 antibody
    • Type-II keratin Kb1 antibody
    see all

References for Anti-Cytokeratin antibody [CK 210 and CK 211 (AE1+AE3] (ab115963)

ab115963 has not yet been referenced specifically in any publications.

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