Anti-Cytomegalovirus AD169 Late antigen antibody [QB1/06] (ab49211)

Overview

  • Product nameAnti-Cytomegalovirus AD169 Late antigen antibody [QB1/06]
  • Description
    Mouse monoclonal [QB1/06] to Cytomegalovirus AD169 Late antigen
  • Tested applicationsSuitable for: IHC-Fr, IHC-Pmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with Cytomegalovirus. Not yet tested in other species.
  • Immunogen

    Partially purified extracts of human embryonic lung fibroblasts infected with CMV strain AD169

  • Positive control
    • CMV infected tissue.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 15mM Sodium Azide
    Constituents: Tissue culture supernatant
  • PurityTissue culture supernatant
  • ClonalityMonoclonal
  • Clone numberQB1/06
  • MyelomaNS0
  • IsotypeIgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab49211 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr
IHC-P
  • Application notesIHC-Fr: 1/50.
    IHC-P: 1/50. Heat mediated antigen retrieval is recommended before commencing with IHC staining protocol. Use 60 minutes primary antibody incubation at 25oC and standard ABC technique.


    Is unsuitable for WB.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceCytomegalovirus (CMV) is a member of the Herpes virus family. Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid which is embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope that is decorated with virus-specific glycoprotein spikes. The viral genes are co-ordinately expressed in groups at various times after infection. Early viral proteins are expressed in the nucleus of infected cells within 3 to 24 hours of infection prior to the commencement of viral DNA replication. This is followed by expression of the early intermediate genes, which encode enzymes required for viral DNA replication. After 48 to 72 hours, a number of late viral antigens may be demonstrated in the nuclei and cytoplasm of infected cells. CMV strain AD169 is a laboratory-adapted strain. It appears to lack a 15kb region of the 200kb genome that is present in clinical isolates. This region contains 19 open reading frames whose functions have yet to be elucidated. AD169 is also unique in that it is unable to enter latency and nearly always assumes lytic growth upon infection.
    • Alternative names
      • HCMV antibody
      • HHV 5 antibody
      • Human Herpesvirus 5 antibody
      • Tegument protein antibody

    References for Anti-Cytomegalovirus AD169 Late antigen antibody [QB1/06] (ab49211)

    ab49211 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"