Overview

  • Product nameCytomegalovirus AD169 protein

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • Additional sequence informationThe strain used to infect CMV antigens is the AD169 strain, which is a crude extract of the native CMV antigen.

Specifications

Our Abpromise guarantee covers the use of ab81698 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1M Glycine, pH 9.3-9.7

General Info

  • Alternative names
    • HCMV
    • HHV5
    • Human Herpesvirus 5
    • UL55 (strain AD169)
  • RelevanceCytomegalovirus (CMV) is a member of the Herpes virus family. Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid which is embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope that is decorated with virus-specific glycoprotein spikes. The viral genes are co-ordinately expressed in groups at various times after infection. Early viral proteins are expressed in the nucleus of infected cells within 3 to 24 hours of infection prior to the commencement of viral DNA replication. This is followed by expression of the early intermediate genes, which encode enzymes required for viral DNA replication. After 48 to 72 hours, a number of late viral antigens may be demonstrated in the nuclei and cytoplasm of infected cells. Cytomegalovirus strain AD169 is a laboratory-adapted strain and appears to lack a 15kb region of the 200kb genome that is present in clinical isolates. This region contains 19 open reading frames whose functions have yet to be elucidated. AD169 is also unique in that it is unable to enter latency and nearly always assumes lytic growth upon infection.

References for Cytomegalovirus AD169 protein (ab81698)

ab81698 has not yet been referenced specifically in any publications.

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